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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۳، شماره ۱، صفحات ۷-۱۰
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عنوان انگلیسی Evaluation of response, tolerability and toxicity of new chemotherapeutic regimen in advanced Gastric Cancer
چکیده انگلیسی مقاله Background: This study testing the effectiveness ,toxicity and tolereability of new chemotherapeutic regimen (consist of Irinotecan 5-FU and Leucovorin) in locally advanced and metastatic Gastric Cancer. Patients and Methods: Patients with locally advanced gstric cancer (atleast stage 3)or metastatic gastric cancer that no treated previously with chemotherapeutic agents entered onto this study. Treatment consist of 6-12 cycles (every 2 weeks) with Irinotecan(CPT-11)140mg/m 2 iv,Lecovorin100mg/m 2 iv ,followed by 5-FU 400mg/m 2 (in4hours)and then 5-FU 1200m 2 (ci in 48h),all cycles given every 2 weeks and repeated atleast for 6 cycles(6-12 cycles ). Results: Ten(10) patients were enrolled and eligible patients received this protocol therapy.The over all response rate was 60% and 10% complete response,and50% with partial response and 10% stable disease. Median survival was 13 months and median event free survival was 8 months. The major toxicity was Neutropenia (grade 4) in 3 cases(30%), that two cases died in neutropenic sepsis feature.Grade 4 anemia was observed in one case that needs to transfusion therapy. Other mild side effect and toxicity of this protocol therapy were: Grade 1 neutropenia(10%),mild thrombocytopenia(10%),mild diarrhea (40% )mild nausea and vomiting (60%)and lethargia and mucositis were not seen. Conclusion: This protocol consist of Irinotecan iv bolous that followed with Leucovorin and 5-FU in 4h and then 5-FU in 48h ci is very active in patients with locally advanced and metastatic Gastric Cancer. Diarrhea and mucositis were less than other reports. Future trials in large series need to documented effectiveness and tolereability and toxicity of this new protocol.
کلیدواژه‌های انگلیسی مقاله Irinotecan,Leucovorin,5fluorouracil,Gastric cancer
نویسندگان مقاله محمد علی مشهدی | mohammad ali mashhadi
hematology- oncology department, ali ebne abitaleb hospital, zahedan university of medical sciences, zahedan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/200
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