این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Hematology-Oncology and Stem Cell Research، جلد ۶، شماره ۲، صفحات ۱۷-۲۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Frequency of Hereditary Coagulation Risk Factors in Deep Vein Thrombosis Patients Referred to Iranian Blood Transfusion Organization, Kermanshah
چکیده انگلیسی مقاله Introduction: The main inhibitors of coagulation pathway are antithrombin (AT), protein C and protein S. These inhibitors are necessary to prevent thromboembolism. Hereditary deficiency of inhibitors is the main cause of alteration in balance between the anti-clotting and the formation of thrombin. Patients with this abnormality are susceptible to venous thromboembolism (VTE). Two major clinical manifestation of VTE are deep vein thrombosis (DVT) and pulmonary embolism (PE). The aim of present study was to investigate the frequency of coagulation inhibitor proteins and resistance to activated protein C (APC-R) in DVT patients from Kermanshah province of Iran with Kurdish ethic background. Materials and methods: We investigated all patients with thrombophilia who referred to Iranian Blood Transfusion Organization from May 2011 to March 2012. The levels of protein C, protein S and antithrombin were measured using STAGO kits, France (Diagnostica Stago) and the APC-R level was detected using Pefakit ® kit. Results: After excluding patients with confounding factors, 54 patients were remained. Our results showed that acquired risk factors are the most common causes of DVT in the present study. In our study protein C deficiency was found to be the most hereditary risk factor followed in frequency by APC-R. Also, in 16 patients (29.6%) there were combined hereditary risk factors with deficiency in 2 or 3 factors. Conclusion: Our results showed protein C deficiency was the prevalent cause of DVT in our patients. Also, different pattern of hereditary risk factors in our patients compared to other regions of Iran could be attributed to different ethnic background of our patients.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله مهرداد پاینده | mehrdad payandeh
medical biology research center, kermanshah university of medical science, kermanshah, iran.


هوشنگ یوسفی | hoshang yousefi
blood transfusion research center, high institue for research and education in transfusion medicine,science, kermanshah, iran.

سازمان اصلی تایید شده: سازمان انتقال خون ایران (Blood transfusion research center)

محمد عرفان زارع | mohammad erfan zare
medical biology research center, kermanshah university of medical science, kermanshah, iran; student


عاطفه نصیر کنسستانی | atefeh nasir kansestani
medical biology research center, kermanshah university of medical science, kermanshah, iran; student


زهره رحیمی | zohreh rahimi
medical biology research center, kermanshah university of medical science, kermanshah, iran; departm


داریوش پورمند | dariush pourmand
department of medical lab science, paramedicine faculty, kermanshah university of medical science, kermanshah, iran


امیر حسین هاشمیان | amir hossein hashemian
department of biostatistics, faculty of public health, kermanshah university of medical science, kermanshah, iran


محمود آیین فر | mahmood aeinfar
student research committee, electronic department, faculty of technology, islamic azad university,kermanshah, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مهرنوش آیین فر | mehrnoush aeinfar
medical biology research center, kermanshah university of medical science, kermanshah, iran.


فرهاد شاویسی زاده | farhad shaveisi zadeh
departments of medical genetics, faculty of medicine, sahid beheshti university of medical science, kermanshah, iran
نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/330
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات