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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۸، شماره ۴، صفحات ۳۰-۳۸
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عنوان انگلیسی Outcome of allogeneic hematopoietic stem cell transplantation in patients with hematological malignancies.
چکیده انگلیسی مقاله Introduction: Allogeneic hematopoietic stem cell transplantation is a potentially curative treatment modality for hematological malignancies. We evaluated the outcome of patients suffering from hematological malignancies, including acute leukemias, chronic myeloid leukemia and myelodysplastic syndrome after allogeneic transplantation. Methods: All patients having hematological malignancies with HLA identical sibling donors who underwent allogeneic transplantation were included. Pre-transplant workup consisted of complete blood counts, evaluation of liver, kidneys, lungs, infectious profile, chest X-ray, paranasal sinus roentgenograms and dental review. Donors were given G-CSF at a dose of 5-10 μg/kg/twice daily for five days prior to harvest. The conditioning regimens included cyclophosphamide, busulfan and total body irradiation. Results: A total of 41 allogeneic transplants were performed for hematological malignancies from April 2004 to December 2012. There were 31 males and 10 females. Median age ± SD was 28 ± 11.7 years (range 8 - 54 years). A mean of 7.7×108±1.5 mononuclear cells/kg were infused (range:6.2-9.2×108/kg). The median time to white cell recovery was 19±4 days (range:15-23 days). Transplant related mortality was 19.5%. The median overall survival was 53.6 months. Overall survival at a median follow up of 37 months was 67%. Conclusion: Allogeneic stem cell transplantation is an effective treatment option in patients with hematological malignancies. Our outcomes are comparable with results from neighboring countries as well as the western world.
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نویسندگان مقاله محمد faizan زاهد | mohammad faizan zahid
medical college, the aga khan university, karachi, pakistan.


ناتاشا علی | natasha ali
departments of pathology amp;amp; microbiology and oncology, the aga khan university, karachi, pakistan.


محمد usman شیخ | mohammad usman shaikh
departments of pathology amp;amp; microbiology and oncology, the aga khan university, karachi, pakistan.


سلمان naseem عادل | salman naseem adil
departments of pathology amp;amp; microbiology and oncology, the aga khan university, karachi, pakistan.
نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/406
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