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Archives of Breast Cancer، جلد ۴، شماره ۱، صفحات ۱۰-۱۵
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عنوان انگلیسی Inherent Radiation Sensitivity of Lymphocytes of Triple Negative (TN) and Luminal A: A Comparison Between Patients with Breast Cancer and Normal Individuals as Assayed by the Micronucleus Test
چکیده انگلیسی مقاله Background: About 83% of patients with breast cancer (BC) undergo radiation therapy. These patients show various degrees of mild to acute reactions during and after the completion of treatment.The aim of this study was to compare inherent radiosensitivity of gamma-irradiated G0-lymphocytes between BC patients and normal individuals using cytokinesis blocked micronucleous assay. Methods: Three to 4 mL blood was drawn in heparinized syringes from patients and normal individuals. A portion of the sample was irradiated with gamma rays at a dose of 300 cGy. Irradiated and non-irradiated samples were cultured in complete RPMI-1640 culture medium. A standard cytokinesis-blocked micronucleus assay protocol was followed for the preparation of binucleate lymphocytes. Slides were prepared and stained in Giemsa. Thousand binucleate cells were scored for the presence of micronucleus (MN). Data were statistically analyzed using SPSS software. Results: The results showed that the background frequency of micronuclei in both groups of control and Luminal A (LA) patients was nearly similar and relatively low but was significantly higher in triple negative BC (TNBC) patients Significantly different (P< 0.01). The irradiation of lymphocytes led to a high frequency of MN in control and LA patients, relatively higher in LA patients (P< 0.001); but the frequency of MN was considerably lower in TNBC patients after irradiation. Conclusions: The results indicated radio-sensitivity of LA patients but radio-resistance in TNBC patients. This different reaction of lymphocytes of patients with BC might be due to different status of genome instability in these patients.
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نویسندگان مقاله حسن نصرتی | hassan nosrati
cancer research center, cancer institute of iran, tehran, iran


حسین مزدارانی | hossein mozdarani
department of medical genetics, faculty of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

پیمان حداد | peyman hadad
radiation oncology research center, cancer institute, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

رامش عمرانی پور | ramesh omranipour
cancer research center, cancer institute of iran, tehran, iran


سحر مزدارانی | sahar mozdarani
cytogenome medical genetics laboratory, ale-ahmad highway, parvaneh street, chamran medical building, tehran, iran


محسن بخشنده | mohsen bakhshandeh
department of radiology technology, allied health school, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

سهیل مزدارانی | sohail mozdarani
cytogenome medical genetics laboratory, ale-ahmad highway, parvaneh street, chamran medical building, tehran, iran


فرهاد شاهی | farhad shahi
cancer research center, cancer institute of iran, tehran, iran
نشانی اینترنتی http://archbreastcancer.com/index.php/abc/article/view/118
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/359/article-359-393467.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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