این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۹۷-۹۷
عنوان فارسی P ۶۶: A Review of Novel Biomarkers Involved in the Neuroinflammation Caused by Human T Lymphotropic Virus-۱
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P 66: A Review of Novel Biomarkers Involved in the Neuroinflammation Caused by Human T Lymphotropic Virus-1
چکیده انگلیسی مقاله HTLV-1 is the causative agent for a neurologic disease named HTLV-I- associated myelopathy/tropical spastic paraparesis (HAM/TSP). Paraparesis of the lower limbs which appears gradually is the most common clinical feature of this disease. It has been shown that the indirect involvement of the nervous system by lymphocytes is more probable than the direct attack of the virus to the neurons. HTLV-1 infected CD4+ T cells may primarily contribute to development of HAM/TSP. It has recently been shown that ex vivo CD80+ B cells positively correlating to disease severity. Moreover, CD4+ CD25+ CCR4+ T cells, which mainly include suppressive T cell subsets such as regulatory T (Treg) cells under healthy conditions, have been demonstrated as the predominant viral reservoir of HTLV-1 in HAM/TSP. This unique T cell subset is shown to be abnormally increased and functionally altered in this retrovirus-associated inflammatory disorder of the central nervous system. On the other hand, HAM/TSP patients demonstrate reductions in the amount and efficacy of cellular components of innate immunity as the numbers and functions of CD56+ CD16+ natural killer (NK) cells in HAM/TSP patients are significantly lower than those observed in healthy controls. Another study has revealed that HBZ (an important HTLV-1-encoded protein) is exclusively localized in the cytoplasm of peripheral blood mononuclear Cells (PBMC) from patients suffering of HAM/TSP. Long Terminal Repeat (LTR) Circular DNA is also presented as a marker of active viral replication. LTR circles were detected both in chronically infected cells lines and also in the PBMCs of almost all HTLV-1 positive patients. Involvement of miRNAs in the HTLV-1 life cycle and in the progression of HAM/TSP has also recently gained notice. Studies of the epidemiology and pathogenesis of HAM/TSP have led to the identification of several biomarkers. However, these findings have not yet led to an optimal therapeutic strategy for this neurological disease.
کلیدواژه‌های انگلیسی مقاله HTLV-1, HAM/TSP, Biomarker
نویسندگان مقاله سمانه ابوالبشری | samaneh abolbashari
department of modern sciences and technology, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

زهرا مشکات | zahra meshkat
antimicrobial resistance research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

مجید غیور مبرهن | majid ghayour mobarhan
a. department of modern sciences and technology, school of medicine, mashhad university of medical sciences, mashhad, iran b. cardiovascular research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-916&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-393370.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات