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Iranian Journal of Public Health، جلد ۴۶، شماره ۴، صفحات ۵۳۰-۵۳۶
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عنوان انگلیسی FGF-23, Klotho and Vitamin D Levels in Scleroderma
چکیده انگلیسی مقاله Background: Scleroderma is a chronic connective tissue disease of unknown etiology. Vitamin D and parathyroid hormone (PTH) that play particular functions in calcium and phosphate homeostasis may be involved in the etiology of this disorder. Klotho, the co-receptor of the fibroblast growth factor 23 (FGF-23), can interfere with calcium and phosphate metabolism. The purpose of this study was to evaluate serum Klotho, FGF-23, intact PTH (iPTH) and vitamin D levels in scleroderma patients compared with the healthy controls. Methods: The study was performed in Biotechnology Research Center, Tabriz University of Medical Sciences (TUMS) from 2014-2015. Sixty scleroderma patients based on the classification criteria of systemic sclerosis and 30 age- and sex-matched healthy controls were included in this study. Serum Klotho, FGF-23, 25-hydroxy vitamin D (25-OH Vit D), and iPTH levels were analyzed using ELISA. Results: Serum levels of Klotho and 25-OH Vit D in the scleroderma patients were lower than those in the healthy controls ( P ˂0.001). In addition, scleroderma patients had higher serum iPTH levels than the controls ( P < 0.001). There was no significant difference in serum FGF-23 levels between the patients and controls ( P =0.202). Conclusion: The decreased serum Klotho, 25-OH Vit D, and increased iPTH levels in the scleroderma patients may be associated with the pathogenesis of this disease and could be considered a future therapeutic target.
کلیدواژه‌های انگلیسی مقاله FGF-23, Klotho, Scleroderma, 25-hydroxy vitamin D
نویسندگان مقاله روان احمدی | ravan ahmadi


مهرزاد حاجعلیلو | mehrzad hajialilo


امیر قربانی حق جو | amir ghorbanihaghjo


علی مطاع | ali mota


سینا رییسی | sina raeisi


نسرین بارگاهی | nasrin bargahi


محمد ولیلو | mohammad valilo


فرحناز عسکریان | farahnaz askarian


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/9763
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-391531.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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