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Archives of Anesthesiology and Critical Care، جلد ۳، شماره ۲، صفحات ۳۰۴-۳۰۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
High Dose but not Low Dose Granisetron Decreases Incidence and Severity of Post Anesthesia Shivering (PAS) and Postoperative Nausea and Vomiting (PONV) following Lower Abdominal Surgeries under Spinal Anesthesia |
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| چکیده انگلیسی مقاله |
from general and regional anesthesia. The incidence of this complication is reported to be 40-70% among patients. PAS occurrence depends on various factors such as age, gender and drugs used in anesthesia and surgery time. Granisetron is a serotonin 5HT3 receptor antagonist. Beneficial effects of such drugs have been shown in a limited number of studies. In this study, preventive effects of granisetron in prevention of shivering, nausea and vomiting following spinal anesthesia were evaluated in patients undergoing lower abdominal surgery. Methods: One hundred and five patients aged 18-60 years and with ASA class I or II who were scheduled to undergo elective lower abdominal surgery under spinal anesthesia were studied in 3 groups of 35 patients. After spinal anesthesia, group L received low dose granisetron with a dose of 10μg/kg, group H received high dose granisetron with a dose of 40 μg/kg and group C received normal saline as placebo. After leaving the operating room, patients were monitored in terms of shivering occurrence, time and severity of it and incidence of nausea and vomiting. Results: Incidence of shivering, nausea and vomiting was significantly lower in group H than C. (P=0.009 and 0.008, respectively). However, there was no significant difference between L and C or L and H groups in terms of shivering, or nausea and vomiting occurrence. No side effects of granisetron were observed in the study. Conclusion: High dose granisetron with dose of 40μg/kg significantly reduced the prevalence and severity of PAS and PONV in comparison to placebo. |
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| نویسندگان مقاله |
عباسعلی دهقانی | abbasali dehghani
tabriz university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
حسن محمدی پور انوری | hassan mohammadi poor anvari
tabriz university of medical sciences
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
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| نشانی اینترنتی |
http://aacc.tums.ac.ir/index.php/aacc/article/view/109 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/371/article-371-385660.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
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| نوع مقاله منتشر شده |
Research Article(s) |
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