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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۶۴-۶۴
عنوان فارسی P ۳۳: Effect of Alcoholic Extract of Rosmarinus officinalis L. and Rosmarinic Acid on Inflammation Induced by Chronic Constriction Injury (CCI) Model of Neuropathic Pain in Rats
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عنوان انگلیسی P 33: Effect of Alcoholic Extract of Rosmarinus officinalis L. and Rosmarinic Acid on Inflammation Induced by Chronic Constriction Injury (CCI) Model of Neuropathic Pain in Rats
چکیده انگلیسی مقاله Introduction: Rosemary, Rosmarinus (R.) officinalis L. is a well-known plant with several useful properties such as analgesic, anti-inflammatory and anti-neurodegenerative. It has been used in folk medicine to alleviate rheumatic pain, stomachache and dysmenorrhea. Rosemary has several constituents such as rosmarinic acid which can be responsible for therapeutic properties been noted with rosemary. The aim of this study was to investigate the potential anti-inflammatory effects of R. officinalis and rosmarinic acid in a rat model of sciatic nerve chronic constriction injury (CCI)-induced neuropathic pain to verify usage of rosemary in folk medicine. Materials and Methods: Rats underwent CCI, were treated  with either normal saline, ethanolic extract of aerial parts of R. officinalis (400 mg/kg, i.p.) or rosmarinic acid (40 mg/kg, i.p.) from the day of surgery (day 0) for 14 days. The anti-inflammatory effects of R. officinalis extract and rosmarinic acid were evaluated by assessing the levels of some spinal inflammatory markers including cyclooxygenase-2 (COX2), prostaglandin E2 (PGE-2), interleukin 1 beta (IL-1β), matrix metallopeptidase 2 (MMP2) through western blotting and nitric oxide (NO) production via Griess reaction on days 7 and 14 post-surgery. Results: CCI rats exhibited a marked expression in the levels of inflammatory markers (COX2, PGE-2, IL-1β, MMP2 and NO) on both days 7 (p < 0.001) and 14 (p < 0.001). Rosmarinic acid and ethanolic extract of R. officinalis were able to decrease amounts of mentioned inflammatory markers on both days 7 (p < 0.001) and 14 (p< 0.001). Conclusion: Our data support the traditional use of R. officinalis as an effective remedy for pain relief and inflammatory disorders. It also suggests that the ethanolic extract of R. officinalis and rosmarinic acid through modulating neuro-inflammation might be potential candidates in treating neuropathic pain and different neurological disorders associated with inflammation.
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نویسندگان مقاله محبوبه قاسم زاده رهباردار | mahboobeh ghasemzadeh rahbardar
department of physiology, school of medical sciences, tarbiat modares university, tehran, iran

سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

بهاره امین | bahareh amin
cellular and molecular research center, department of physiology and pharmacology, faculty of medicine, sabzevar university of medical sciences, sabzevar, iran


حسین حسین زاده | hossein hosseinzadeh
pharmaceutical research center, department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-882&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385652.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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