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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۵۷-۵۷
عنوان فارسی P ۲۶: The Protective Effect of Nano-Hesperetin on Memory Disorder Induced by Streptozotocinin Male Rat in Alzheimer Models
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عنوان انگلیسی P 26: The Protective Effect of Nano-Hesperetin on Memory Disorder Induced by Streptozotocinin Male Rat in Alzheimer Models
چکیده انگلیسی مقاله Introduction: Intracerebroventricular (i.c.v.) injection of streptozotocin (STZ) to rodents has been reported as an appropriate model for sporadic dementia of Alzheimer's type (SDAT), characterized by a progressive impairment of memory. However, very little or nothing is known about non-cognitive behavioral effects in the STZ model. This study was carried out in order to show the protective effects of nano-hesperetin on memory disorder in the brains of Alzheimer's animal models. Materials and Methods:  49 male rats were divided into 6 groups: control, sham, disease group (rats were injected with STZ), 2 treatment groups receiving 10 and 20 mg/kg/day of Nano-hesperetin. Then 3 µgr/rat of (STZ) was injected to the cerebroventricular of rats of all groups except the control and sham groups. The control and sham and toxin groups received distilled water orally. The two treatment groups were gavaged by, respectively10, 20 mg/Kg of nano-hesperetin 30 days. Then, three successive weeks, recognition memory was examined by shutl box test. Results: The results showed that injection of STZ increases memory disorders (p≤0.001) and treatment of Nano-hesperetin effectively decrease memory disorders (p< 0.001) and increases duration that spends in light area of Shuttle box (p< 0.01) compared with disease group. Conclusion: the treatment with Nano-hesperetin cause the protect cholinergic neurons against memory disorder in the Alzheimer rat model.
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نویسندگان مقاله الهام خردمند | elham kheradmand
department of biology, faculty of basic sciences, university of mazandaran, babolsar, iran

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

اکبر حاجی زاده | akbar hajizadeh
department of biology, faculty of basic sciences, university of mazandaran, babolsar, iran

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

محبوبه زارع | mahbobeh zare
faculty of herbs, amol university of special modern technologies, amol, iran

سازمان اصلی تایید شده: دانشگاه تخصصی فناوری های نوین آمل (Amol university of special modern technologies)

صدیقه خانجانی جلودار | sedigheh khanjani jelodar
faculty of biology, shahid beheshti university, tehran, iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-875&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385645.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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