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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۵۰-۵۰
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| عنوان فارسی |
P ۱۹: The Effects of Aloe Vera Extract on Brain Edema and Blood-Brain Barrier Permeability after Traumatic Brain Injury |
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| چکیده فارسی مقاله |
لطفاً به چکیده انگلیسی مراجعه شود. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
P 19: The Effects of Aloe Vera Extract on Brain Edema and Blood-Brain Barrier Permeability after Traumatic Brain Injury |
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| چکیده انگلیسی مقاله |
Introduction: Recent studies have reported that the Aloe vera (Aloe barbadensis miller) plant has anti-inflammatory and antioxidant effects. This study evaluated the neuroprotective effects of different doses of Aloe vera extract after traumatic brain injury (TBI) in male rats. Materials and Methods: In this study, 70 male rats were divided into 2 groups; each group consists of 5 of sub-groups as following: sham, TBI, TBI + vehicle, TBI + Aloe vera extract (low dose, 200mg/kg) and TBI + Aloe vera extract (high dose, 400mg/kg) groups. TBI was induced by the Marmarou method, and Aloe vera extract was administrated intra peritoneal (ip) 30 min after TBI. Brain edema was evaluated by measuring brain water content 24 h after the TBI and blood-brain barrier (BBB) permeability was determined by measuring Evans blue dye content 5 h after the TBI. Results: Our results showed that brain water contents was no significant difference in TBI group compared to TBI + vehicle group (P< 0.687). But Aloe vera extract administration after TBI in different doses (200, 400 mg/kg) significantly reduced brain water content in TBI group compared to TBI + vehicle group (P< 0.005). Also blood-brain barrier permeability significantly increased after TBI compared to vehicle group (P< 0.001).In addition there was no significant difference in TBI group compared to TBI + vehicle group (P< 0.742). But Aloe vera extract administration after TBI in different doses (200, 400 mg/kg) significantly reduced blood-brain barrier permeability in TBI group compared to TBI + vehicle group (P< 0.001). Of course, high doses of aloe vera could more effectively reduced the brain blood barrier permeability compared to low dose of aloe vera. Conclusion: The current study, show that the Aloe vera extract may be had neuroprotetection effects after TBI. However, the mechanism(s) for this effect have not yet been elucidated. |
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| کلیدواژه‌های انگلیسی مقاله |
Tbi, Brain edema, Aloe vera |
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| نویسندگان مقاله |
مرضیه شهریاری | marzieh shahriari
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
محمد خاکساری | mohammad khaksari
physiology research center, institute of neuropharmacology, afzalipour school of medicine, kerman university of medical sciences, kerman, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
بهرام بی باک | bahram bibak
faculty of medicine, north khorasanunivercity of medical sciences
affat رامشینی | affat ramshini
neuroscience research center, institute of neuropharmacology, kerman university of medical sciences, kerman, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
عباس شهابی | abbas shahabi
department of biochemistry, kerman university of medical sciences, kerman, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
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| نشانی اینترنتی |
http://shefayekhatam.ir/browse.php?a_code=A-10-24-868&slc_lang=en&sid=fa |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385638.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
تحقیقات پایه در علوم اعصاب |
| نوع مقاله منتشر شده |
پژوهشی |
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