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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۴۷-۴۷
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| عنوان فارسی |
P ۱۶: The Effect of Reducing CCL۱۱ on Multiple Sclerosis Treatment by Using Heterochronic Parabiosis Techniques |
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| چکیده فارسی مقاله |
لطفاً به چکیده انگلیسی مراجعه شود. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
P 16: The Effect of Reducing CCL11 on Multiple Sclerosis Treatment by Using Heterochronic Parabiosis Techniques |
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| چکیده انگلیسی مقاله |
Introduction: Multiple sclerosis is a chronic neuroinflammatory disease that leads to distribute neurodegeneration in the grey and white matter of the brain. In MS, age-related iron accumulation, chronic oxidative injury and activation of microglia are key factors to create neurodegeneration. Also concentration of CCL11 is increased in multiple sclerosis. CCL11 can amplify glutamate mediated neurotoxicity and inhibit neurogenesis. Materials and Methods: A model of Heterochronic Parabiosis is created with joining a sick animal to healthy young animal. Results: It is expected by reducing CCl11, healthy young blood could be effective in slowing and improving disease. Conclusion: Other studies suggest that multiple sclerosis treatment should be based on a combination of anti-inflammatory, regenerative, and neuroprotective strategies. By using heterochronic parabiosis has been shown that, young blood can rejuvenate and improve the regenerative capacity of peripheral tissues and central nervous system in aged animals. GDF11 is a systemic 'pro-youthful' factor in young parabiont, that promote neurogenesis and rejuvenate regeneration capacity of CNS and promote tissue regeneration. So it seems high concentration of GDF11 and low concentration of ccl11 in healthy young parabiont may be effective on regenerative capacity of central nervous system in MS animals. |
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| نویسندگان مقاله |
لیلا کمالی دولت آبادی | leila kamali dolatabadi
department of neuroscience, school of advanced medical sciences and technologies, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
معصومه محمدپور | masoomeh mohamadpour
histomorphometry and stereology research center. shiraz university of medical science. shiraz. iran
سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)
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| نشانی اینترنتی |
http://shefayekhatam.ir/browse.php?a_code=A-10-24-865&slc_lang=en&sid=fa |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385635.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
تحقیقات پایه در علوم اعصاب |
| نوع مقاله منتشر شده |
پژوهشی |
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