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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۴۶-۴۶
عنوان فارسی P ۱۵: Forced Exercise Attenuates Neuropathic Pain in Chronic Constriction Injury Male Rat: An Approach to Oxidative Stress and Inflammation
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عنوان انگلیسی P 15: Forced Exercise Attenuates Neuropathic Pain in Chronic Constriction Injury Male Rat: An Approach to Oxidative Stress and Inflammation
چکیده انگلیسی مقاله Introduction: Peripheral and central nerve injuries cause chronic neuropathic pain in many injured people besides motor disability. Exercise, as a behavioral and non-pharmacological treatment, has beneficial effects on people's general health both for healthy and sick people. Therefore, this study was conducted to examine the effects of exercise on neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve. Materials and Methods: Wistar male rats weighing 200 ± 20 g were randomly divided into five groups (normal, sham, CCI, pre-CCI exercise, and post-CCI exercise group). Once the rats were anesthetized, their sciatic nerve was legated to induce CCI, and they were then housed in separate cages. The rats ran on treadmill at a moderate speed for 3 weeks. Mechanical allodynia and thermal hyperalgesia were determined using von Frey Filament and plantar test, respectively. TNF-α, malondialdehyde, and total antioxidant capacity were measured using Western blot test, thiobarbituric acid, and ferric reducing ability of plasma (FRAP) respectively. Results: The mechanical allodynia (P< 0.05) and thermal hyperalgesia (P< 0.01) in the CCI group were significantly higher than those in the sham group. Exercise after CCI significantly reduced (P< 0.01) mechanical allodynia and thermal hyperalgesia (P< 0.05) against those in the CCI group. Moreover, the level of FRAP in the CCI group was significantly (P< 0.01) lower than that in the sham group, and the level of FRAP in the post-CCI group increased significantly (P< 0.05) against that in the CCI group. The level of MDA did not differ significantly between groups. Level of TNF-α increased significantly in the CCI group (P< 0.001) compared to sham group and decreased significantly in the post-CCI group (P< 0.01) against that in the CCI group. Conclusion: Exercise reduces mechanical allodynia and thermal hyperalgesia induced by CCI. These effects probably mediated by increasing the total antioxidant capacity and reducing the TNF-α inflammation factor.    
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نویسندگان مقاله نصرالله مرادی کر | nasroallah moradi kor
a. research center of physiology, faculty of medicine, semnan university of medical sciences, semnan, iran b. student research committee, faculty of medicine, semnan university of medical sciences, semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

حسینعلی صفاخواه | hossein ali safakhah
laboratory of pain research, research center and department of physiology, faculty of medicine, semnan university of medical sciences, semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

عطیه بازرگانی | atiyeh bazargani
student research committee, faculty of medicine, semnan university of medical sciences, semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

احمدرضا بندگی | ahmad reza bandegi
department of biochemistry, faculty of medicine, semnan university of medical sciences, semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

حمید غلامی پور بدیع | hamid gholami pourbadie
department of physiology and pharmacology, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

بهارک خوش خلق سیما | baharak khoshkholgh sima
department of physiology and pharmacology, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

علی قنبری | ali ghanbari
research center of physiology, faculty of medicine, semnan university of medical sciences, semnan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی سمنان (Semnan university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-864&slc_lang=en&sid=fa
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زبان مقاله منتشر شده fa
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