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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۴۱-۴۱
عنوان فارسی P ۱۰: Safranal Attenuates Quinolinate-Induced Oxidative OLN-۹۳ Cells Death
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
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عنوان انگلیسی P 10: Safranal Attenuates Quinolinate-Induced Oxidative OLN-93 Cells Death
چکیده انگلیسی مقاله Introduction: Quinolinic acid (QA) is a product of tryptophan degradation and its pathologic accumulation has been found to induce neuroinflammatory and demyelinating diseases such as multiple sclerosis via excessive free radicals generation. Recent studies showed Safranal which is the main component of essential oil of saffron, has several pharmacological effects such as antioxidant, anti-inflammatory and neuroprotective properties. The aim of this study was evaluation of the protective effect of Safranal on oxidative OLN-93 cells death induced by QA. Materials and Methods:  Cells were pretreated with Safranal (1-800 𝜇M) for 2 h and then were subjected to QA (8 mM) for 24 h in which the same treatments were applied. Cell viability and the parameters of redox status including the levels of intracellular reactive oxygen species (ROS), and lipid peroxidation were measured using 2-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT), 2,7-dicholorofluorecin diacetate (DCF-DA) and thiobarbituric acid assays, respectively. Results: safranal at concentration ranges of 1-800 μM had no toxic effect on cell viability (p>0.05). Treatment with Safranal significantly increased cell viability following QA insult at concentrations 1-800 𝜇M (p< 0.001). Cytoprotective potential of Safranal also ameliorated ROS accumulation and lipid peroxidation induced by QA. Conclusion: These data suggest that Safranal exhibits oligoprotection potential by means of alleviating oxidative stress parameters.
کلیدواژه‌های انگلیسی مقاله Quinolinic acid, Safranal, OLN-93 cells, Gliotoxicity
نویسندگان مقاله سحر فنودی | sahar fanoudi
pharmacological research center of medicinal plants, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حمیدرضا صادق نیا | hamid r sadeghnia
a. pharmacological research center of medicinal plants, school of medicine, mashhad university of medical sciences, mashhad, iran b. neurocognitive research center, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

آمنه veisifard | ameneh veisifard
department of biology, university of payame noor, mashhad, iran


محمد soukhatanloo | mohammmad soukhatanloo
department of biochemistry, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-859&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385629.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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