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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۷-۷
عنوان فارسی O ۷: KCNK۲ Regulates the Nanoscale Formation of Immune Docking Structures on Brain Endothelial Cells Under Autoinflammatory Conditions
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی O 7: KCNK2 Regulates the Nanoscale Formation of Immune Docking Structures on Brain Endothelial Cells Under Autoinflammatory Conditions
چکیده انگلیسی مقاله KCNK2 was previously shown to regulate immune-cell trafficking into the central nervous system (CNS). Kcnk2-/- mice demonstrated a more severe disease course in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, due to an increased immune-cell migration into the CNS. An upregulation of the cellular adhesion molecules ICAM1 and VCAM1 on brain endothelial cells in Kcnk2-/- was proposed as underlying mechanism. The exact molecular pathways involved are currently unknown. By using super resolution microscopy methods, we were able to identify an altered surface morphology of brain endothelial cells upon inflammation indicated by 200-300 nm high membrane protrusions. Analysis of atomic force microscopy (AFM) images of Kcnk2-/- mouse brain endothelial cells showed a significant increase in number and volume of membrane protrusions. Confocal imaging identified these membrane protrusions as ICAM1- and VCAM1-containing immune-cell docking structures. Kcnk2-/- cells showed alterations of the actin cytoskeleton and an increase of stress fibers already under basal conditions, indicating a regulation of cytokine rearrangement by KCNK2 channels. KCNK2 regulates the nanoscale formation of adhesion molecule-containing immune docking structures on brain endothelial cells under autoinflammatory conditions, thereby regulating leukocyte adhesion and migration into the CNS.
کلیدواژه‌های انگلیسی مقاله Brain, Leukocyte, Structures
نویسندگان مقاله stefanie bock | stefanie bock
institute of translational neurology, department of neurology, university of muenster, muenster, germany


tobias ruck | tobias ruck
institute of translational neurology, department of neurology, university of muenster, muenster, germany


jonas franz | jonas franz
anostic institute, center for nanotechnology, university of muenster, muenster, germany


کریستف riethmüller | christoph riethmüller
anostic institute, center for nanotechnology, university of muenster, muenster, germany


استفان bittner | stefan bittner
department of neurology, university medical center of the johannes gutenberg-university mainz, mainz, germany


sven g meuth | sven g meuth
institute of translational neurology, department of neurology, university of muenster, muenster, germany
نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-825&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385596.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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