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مجله علوم اعصاب شفای خاتم، جلد ۵، شماره ۲، صفحات ۶-۶
عنوان فارسی O ۶: Kininogen Deficiency Ameliorates Neuroinflammation by Reducing Immune Cell Trafficking
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی O 6: Kininogen Deficiency Ameliorates Neuroinflammation by Reducing Immune Cell Trafficking
چکیده انگلیسی مقاله Enhanced immune cell trafficking into the central nervous system (CNS) and disruption of the blood brain barrier are pathophysiological hallmarks of neuroinflammatory disorders like multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). However, recent studies suggest that the coagulation and the contact-kinin system might also be involved in MS development. For instance, it was shown that the coagulation factor XII modulates immune cell function and bradykinin influences the integrity of the blood-brain barrier (BBB). High molecular weight kininogen (HMWK) is a central constituent of the contact-kinin system. Here, we identify HMWK as a critical player in neuroinflammation. Deficiency of HMWK renders mice less susceptible to EAE and was accompanied by decreased numbers of infiltrated lymphocytes into the CNS, whereas the distribution of immune cells was unaltered as determined by flow cytometry analysis. Preliminary in vitro migration experiments showed that HMWK leads to an enhanced immune cell trafficking through an endothelial cell layer. Altogether, our study indicates that HMWK inhibition reduces cell invasion during autoimmune CNS disease and may offer a novel strategy to combat MS
کلیدواژه‌های انگلیسی مقاله Central nervous system, Mice, Animal model
نویسندگان مقاله منیکا merker | monika merker
department of neurology, university of muenster, muenster, germany


susann pankratz | susann pankratz
department of neurology, university of muenster, muenster, germany


الکساندر m هرمان | alexander m herrmann
department of neurology, university of muenster, muenster, germany


heinz wiendl | heinz wiendl
department of neurology, university of muenster, muenster, germany


کریستف kleinschnitz | christoph kleinschnitz
department of neurology, university hospital würzburg, würzburg, germany


kerstin göbel | kerstin göbel
department of neurology, university of muenster, muenster, germany


sven g meuth | sven g meuth
department of neurology, university of muenster, muenster, germany
نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-824&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-385595.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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