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Iranian Journal of Parasitology، جلد ۵، شماره ۱، صفحات ۴۷-۵۴
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عنوان انگلیسی The Role of Liposomal CpG ODN on the Course of L. major Infection in BALB/C Mice
چکیده انگلیسی مقاله Background : Historically, leishmanization is the most effective protective measure against Cutaneous Leishmaniasis (CL), CL lesion induced by leishmanization sometimes takes a long time to heal. Ma­nipulation of leishmanization inoculums needed to induce a mild and acceptable CL lesion. The aim of this study was to explore if liposomal form of CpG ODN (Cytosin phosphate Guanin Oligodeoxynu­cleotides) mixed with Leishmania major would induce a milder lesion size in Balb/c mice. Methods: This study was performed in Biotechnology Research Center, Mashhad, and Center for Re­search and Training in Skin Diseases and Leprosy, Tehran, Iran during 2008-2009. mice were subcutaneously (SC) inoculated with L. major mixed with liposomal form of CpG ODN, or L. major plus free CpG ODN, or L. major mixed with empty liposomes or L. major in PBS. The lesion onset and the size of lesion were recorded; the death rate was also monitored. Result : Footpad thickness was significantly ( P < 0.01) smaller, death rate was also significantly ( P < 0.05) lower in the mice received L. major mixed with liposomal CpG ODN or free CpG ODN than control groups received L. major in PBS or L. major plus liposomes, also mice which received L. ma­jor mixed with CpG ODN in soluble form showed a significantly ( P < 0.001) smaller lesion size than control groups. Conclusion : CpG ODN seems to be an appropriate immunopotentiator mixed with Leishmania stabi­late in leishmanization.
کلیدواژه‌های انگلیسی مقاله CpG ODN,Liposome,Leishmania major,BALB/c
نویسندگان مقاله h حجازی | h hejazi
department of parasitology, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

m تسبیحی | m tasbihi
department of parasitology, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

mr جعفری | mr jaafari
biotechnology research center and nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

a بدیعی | a badiee
biotechnology research center and nanotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

n پسته چیان | n pestechian
department of parasitology, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

علی | a javadi
department of social medicine, qazvin university of medical sciences, qazvin, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)

a خامسی پور | a khamesipour
center for research and training in skin diseases and leprosy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/126
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