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Iranian Journal of Parasitology، جلد ۸، شماره ۳، صفحات ۴۴۹-۴۵۸
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عنوان انگلیسی Protection Efficacy of Multivalent Egg Yolk Immunoglobulin against Eimeria tenella Infection in Chickens.
چکیده انگلیسی مقاله Background: To control avian coccidiosis with drug-independent strategy effec-tively and safely, multivalent hyperimmune egg yolk immunoglobulin (IgY) was prepared and its ability to protect against Eimeria tenella infection was evaluated. Methods: Hens were orally immunized with live oocysts of 5 species of Eimeria for six times, antibody titers in serum and yolk were monitored by indirect enzyme-linked immunosorbent assay. The specific IgY was isolated, purified and lyophi-lized. IgY powder was orally administrated as dietary supplement in newly hatched chicks at various dosages. Birds were orally challenged with 10000 sporulated oo-cysts of E. tenella at 10 days of age, weighed and killed at 8 days post challenge, and the protective effect was assessed. Results : The averge yeid of IgY was 9.2 mg/ml yolk, the antibody titer of IgY reached to 1:163840 per mg with the purity up to 98%. Chickens fed IgY resulted in reduced mortality, increased body weight gain (BWG), reduced oocyst shedding, reduced caecal lesion score and increased anti-coccidial index. In terms of BWG and caecal lesion, IgY significantly enhanced the resistance of bird at ≥ 0.05% of IgY in the diet when compared with the challenged control group ( P < 0.05). No significant difference was observed at dosage ≥ 0.5% and 1.0% when BWG and caecal lesion were compared with the sodium salinomycin control group, respec-tively ( P >0.05). Conclusion : Supplementing newly hatched chicks with Eimeria -specific IgY repre-sents a promising strategy to prevent avian coccidiosis.
کلیدواژه‌های انگلیسی مقاله Coccidiosis,Eimeria tenella,IgY,Passive immunization
نویسندگان مقاله jj xu | jj xu
ministry of education key lab for avian preventive medicine, yangzhou university, yangzhou, china.


cz ren | cz ren
ministry of education key lab for avian preventive medicine, yangzhou university, yangzhou, china.


ss ونگ | ss wang
ministry of education key lab for avian preventive medicine, yangzhou university, yangzhou, china.


dd liu | dd liu
ministry of education key lab for avian preventive medicine, yangzhou university, yangzhou, china.


lq cao | lq cao
ministry of education key lab for avian preventive medicine, yangzhou university, yangzhou, china.


jp تایو | jp tao
ministry of education key lab for avian preventive medicine, yangzhou university, yangzhou, china.
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/470
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