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Tanaffos، جلد ۲۴، شماره ۱، صفحات ۶۲-۶۸
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عنوان انگلیسی Comparison between Levofloxacin and Azithromycin in Short-term Spirometry and Oxygen Saturation Indices in Patients with Exacerbated Bronchiectasis: A Randomized Double-blind Clinical Trial
چکیده انگلیسی مقاله Background: Bronchiectasis is a chronic pulmonary disease characterized by abnormal and permanent dilatation of the airways in the lung. This study was conducted to compare the effect of levofloxacin with azithromycin in improving the lung function of these patients.
Materials and Methods: In this parallel double-blinded randomized clinical trial, 72 patients with exacerbated bronchiectasis were included and randomly divided into two intervention groups. One group was treated with levofloxacin (500 mg daily for two weeks at first and then 250 mg daily in the next four weeks), and the other group with azithromycin (500 mg daily in the first two weeks and then with a dose of 250 mg daily for the next four weeks) for 6 weeks. The pulmonary function tests were performed and analyzed at the beginning of the study, two, four, and six weeks after the intervention.
Results: The mean expiratory volume in the first second (FEV1) and the percentage of oxygen saturation (O2Sat) in the levofloxacin group and the azithromycin group were not significantly different at the beginning of the study. Importantly, six weeks after the initiation, the mean FEV1 (61.02±8.54% vs. 56.88±7.13%, p=0.029) and O2Sat (91.00±1.72% vs. 85.44±1.77%, p=0.001) in the levofloxacin group were significantly higher than those in the azithromycin group.
Conclusion: The present study showed that the favorable effect of six-week therapy with levofloxacin compared to azithromycin can significantly increase the pulmonary values of FEV1 and O2Sat in patients with exacerbated bronchiectasis.
کلیدواژه‌های انگلیسی مقاله Levofloxacin,Azithromycin,Bronchiectasis,Respiratory function
نویسندگان مقاله Maryam Hajimirghasemi |
Department of Respiratory, Faculty of Medicine, Shahroud University of Medical Science, Shahroud, Iran

Mahdi Behi |
Department of Pharmacology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Hoofer Rafiei |
Department of Nephrology, Faculty of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran

Mohammad Bagher Sohrabi |
Faculty of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran

Babak Gholamine |
Department of Pharmacology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mahsa Forghani |
Department of Internal medicine, Faculty of Medicine, Shahroud University of Medical Science, Shahroud, Iran

نشانی اینترنتی https://www.tanaffosjournal.ir/article_733721_81e5c6392e2feb14ddc49235f62ea737.pdf
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