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Iranian Biomedical Journal، جلد ۲۹، شماره ۶، صفحات ۳۶۰-۳۷۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Regulatory Signaling Pathways in Ovarian Cancer Stem Cells: Their Role in Tumor Progression and Therapeutic Strategies
چکیده انگلیسی مقاله
In ovarian cancer, ovarian cancer stem cells (OCSCs) not only contribute to tumor formation but also drive the progression, metastasis, and chemoresistance. The defining properties of OCSCs are sustained through the Wnt/β-catenin, Notch, and Hedgehog signaling pathways, which can synergize rather than act independently to form a triad that enhances key functional capabilities of OCSCs. Various therapeutic agents have been studied to target these pathways in OCSCs, including γ-secretase inhibitors (nirogacestat), smoothened inhibitors (vismodegib and sonidegib), and Wnt/β-catenin inhibitors (PRI-724 and ipafricept). While these agents have demonstrated antitumor activity in preclinical and early clinical studies, their clinical use remains challenging due to compensatory interactions among signaling pathways, which diminish the efficacy of single-agent treatments. To improve treatment outcomes, strategies involving combination approaches and personalized treatments need to be explored. This review aims to summarize current evidence on the role of Wnt/β-catenin, Notch, and Hedgehog signaling pathways in OCSCs and their therapeutic implications in ovarian cancer.
کلیدواژه‌های انگلیسی مقاله Hedgehogs, Ovarian neoplasms, Therapeutics, Wnt signaling pathway
نویسندگان مقاله | Dini Amalia
Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia


| Febriani Febriani
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Riau/District General Hospital Arifin Achmad Riau Province, Pekanbaru, Indonesia


| Arfianti Arfianti
Department of Medical Biology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6344-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cancer Biology
نوع مقاله منتشر شده مقاله مروری
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