این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Biomedical Journal، جلد ۳۰، شماره ۲، صفحات ۱-۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Integrative Modulation of Angiogenesis and Oxidative Stress by Cold Atmospheric Plasma Combined with Anti-PD-1 Therapy in a Mouse Model of Melanoma
چکیده انگلیسی مقاله
Introduction: Melanoma is a highly aggressive form of skin cancer. While immune checkpoint inhibitors, such as anti-PD-1, are effective, the responses among patients vary significantly. Therefore, complementary therapeutic strategies are needed. Cold atmospheric plasma (CAP), which generates reactive species, can influence the tumor microenvironment, oxidative stress, and angiogenesis. This study examined the effects of CAP, alone and in combination with anti-PD-1, on the expression of EGFR and GJA1 in a murine melanoma model.
Materials and Methods: B16-F10 melanoma cells were injected subcutaneously into female C57BL/6 mice. After tumor formation, the animals were divided into five treatment groups: control, CAP, anti-PD-1, CAP + anti-PD-1, and dacarbazine. At the endpoint, tumor tissues were collected, and the mRNA levels of EGFR and GJA1 were quantified using RT-qPCR.
Results and Discussion: The CAP + anti-PD-1 combination resulted in a significantly greater downregulation of EGFR and GJA1expression compared to the monotherapies, indicating a synergistic effect between the two treatments. Considering that EGFR promotes angiogenesis and GJA1 modulates cellular redox signaling and intercellular communication, the combination therapy appears to exert a strong inhibitory effect on these pathways.
Conclusion: Our findings suggest that CAP-based combination therapy could serve as a promising strategy for enhancing the efficacy of immunotherapy in melanoma.
 
""
کلیدواژه‌های انگلیسی مقاله Angiogenesis, Anti-PD-1, Cold atmospheric plasma, Melanoma, Oxidative stress
نویسندگان مقاله | Forouzan Bousaeedi


| Alireza Rafiei


| Zeinab Rostami


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-864&slc_lang=other&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده other
موضوعات مقاله منتشر شده Related Fields
نوع مقاله منتشر شده کنگره
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات