این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Radiation Research، جلد ۲۴، شماره ۱، صفحات ۳۷-۴۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی X-ray resistance in multidrug-resistant Gram-negative nosocomial pathogens: An in vitro assessment of bacterial survival across radiation dose thresholds
چکیده انگلیسی مقاله
Background: X-rays used for diagnostic and therapeutic purposes have various effects on nosocomial pathogens. Thanks to advanced repair mechanisms, bacteria, among the earliest life forms on Earth, can survive exposure to ionizing radiation. It is important to determine the radiation threshold for nosocomial pathogens with drug resistance. In this study, we investigated the survival responses of Gram-negative bacteria, which exhibit antimicrobial resistance in the clinical setting, to different doses of ionizing radiation. Materials and Methods: Bacterial isolates obtained from pure culture and adjusted to 0.5 McFarland turbidity were exposed to radiation doses of 0 (Control), 12.5, 25, 50, and 100 Gy in an X-ray machine used in clinical treatment. The results obtained were evaluated by comparing the number of microorganisms that remained alive after exposure to X-ray radiation with the control group. Results: No significant reduction in bacterial growth was observed following exposure to 12.5 Gy and 25 Gy. At 50 Gy, 3 isolates exhibited reduced viability. Exposure to a dose of 100 Gy induced a substantial reduction in Colony-Forming Unit (CFU) counts in 14 isolates and caused complete lethality in P. mendocina. These effects followed a dose-dependent trend. Conclusions: MDR Gram-negative pathogens are resilient against radiation doses typically applied in clinical practice. Bactericidal effects were only observed at doses ≥50 Gy, levels far exceeding what is biologically tolerable for human tissues. These findings underscore the need for precise dose classification when discussing bacterial radiation responses and emphasize that such high doses are suitable only for external sterilization, not patient-based applications.
کلیدواژه‌های انگلیسی مقاله Radiation tolerance, drug resistance, X-rays, pathogens.
نویسندگان مقاله | F. Orhan
Vocational School of Health Services, Ataturk University, Erzurum, Türkiye


| Y. Sahin
Vocational School of Health Services, Ataturk University, Erzurum, Türkiye


| A. Zortul
linic of Radiation Oncology, Erzurum Training and Research Hospital, Erzurum, Türkiye


| A. Bastopcu
Department of Clinical Microbiology, Faculty of Medicine, Ataturk University, Erzurum, Türkiye


| Ö. Barış
Department of Biology, Science Faculty, Kyrgyz-Turkish Manas University, Bishkek, Kyrgyz Republic
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-1452&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات