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The Journal of Tehran University Heart Center، جلد ۲۰، شماره ۴، صفحات ۳۱۰-۳۲۲
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عنوان انگلیسی Reduced Left Ventricular Global Longitudinal Strain in the Coronary Slow Flow Phenomenon: A Systematic Review and Meta-Analysis
چکیده انگلیسی مقاله Background: The coronary slow flow phenomenon (CSFP) involves delayed coronary artery filling without obstruction and is associated with angina and myocardial ischemia. This meta-analysis assessed the link between CSFP and impaired left ventricular global longitudinal strain (LVGLS), a marker of subclinical myocardial dysfunction. Methods: A systematic search (PubMed, Embase, Scopus up to January 2025) identified 18 observational studies comparing LVGLS and layer-specific strain in patients with CSFP vs controls with normal coronary flow. Results: Patients with CSFP showed significantly reduced LVGLS vs controls (SMD, 1.22; 95% CI, 0.69 to 1.75). Layer-specific analysis revealed impairment across all myocardial layers, most pronounced in the endocardium (SMD, 0.79; 95% CI, 0.21 to 1.38). While left ventricular ejection fraction (LVEF) was preserved, LVGLS demonstrated moderate-to-high diagnostic accuracy for CSFP (AUC, 0.80; 95% CI, 0.66 to 0.95). Reduced LVGLS independently predicted CSFP (adjusted OR, 1.43; 95% CI, 1.19 to 1.46). Exercise stress effects on LVGLS were inconsistent. Conclusion: CSFP is associated with impaired LVGLS, particularly in the endocardial layer, despite preserved LVEF. LVGLS may serve as a noninvasive marker for subclinical dysfunction in CSFP.
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نویسندگان مقاله | Mahin Seifi Alan
Alborz University of Medical Sciences


| Kobra Hosseini
Alborz University of Medical Sciences


| Sanaz Seifi Alan
Alborz University of Medical Sciences


| Zahra Mirzaei
Alborz University of Medical Sciences


| Peyman Saeedi
Alborz University of Medical Sciences


| Soroush Bahrami
Alborz University of Medical Sciences


| Vahid Shahnavaz
Alborz University of Medical Sciences


| Haniyeh Rashidi
Alborz University of Medical Sciences


| Mahnaz Seifi Alan
Alborz University of Medical Sciences


| Hadith Rastad
Alborz University of Medical Sciences
نشانی اینترنتی https://jthc.tums.ac.ir/index.php/jthc/article/view/2366
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