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Iranian Journal of Public Health، جلد ۵۴، شماره ۱۱، صفحات ۲۴۵۶-۲۴۶۶
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عنوان انگلیسی The Microbial Factors, Trace Elements, and Important Biologi-cal Indicators in Children with Autism Spectrum Disorder: A Meta-Analysis
چکیده انگلیسی مقاله Background: We examined and compared microbiological variables, trace elements, and biological markers in autistic children. Methods: Several databases, including the Cochrane Library, PubMed, OVID, Google Scholar, and Embase, were utilized for data collection and analysis. We studied meta-analysis data and used a continuous model with fixed or random effects to get mean differences (MD) with 95% confidence intervals (CIs). Twenty-seven studies involving 2557 children from 2014 to 2024 were analyzed. Results: Autism spectrum disorder had significantly higher C-reactive protein (MD, 1.25; 95% CI, 0.11-2.39, P=0.03), interleukin 6 (MD: 2.80; 95%CI, 1.13-4.46, P=0.001), serotonin (MD, 111.92; 95%CI, 63.75-160.09, P<0.001), Faecalibacterium (MD, 0.48; 95%CI: 0.29-0.66, P<0.001), and Parabacteroides (MD, 0.20; 95%CI: 0.14-0.26, P<0.001), lower oxytocin (MD, -53.24; 95% CI, -73.39- -33.09, P<0.001), and serum iron (MD, -5.78; 95% CI, -9.43- -2.13, P=0.002) compared to control in children. Conclusion: Autism spectrum disorder had significantly higher C-reactive protein, interleukin-6, serotonin, Faecalibacterium, Parabacteroides, lower oxytocin, and serum iron compared to control in children. Further research studies with larger sample sizes are needed.
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نویسندگان مقاله | Keli Qu
Department of Child Healthcare, Shandong Provincial Third Hospital, Shandong University, Jinan, China


| Zhiliang Gao
Department of Pediatric, Binzhou Hospital of Traditional Chinese Medicine, Binzhou, China


| Cong Chang
Department of Rehabilitation, Binzhou Municipal Hospital, Binzhou, China


| Meizhe Gao
Department of Child Healthcare, Shandong Provincial Third Hospital, Shandong University, Jinan, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/38484
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