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Research in Molecular Medicine، جلد ۱۳، شماره ۱، صفحات ۰-۰
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عنوان انگلیسی Protective Effects of Long-Term High-Intensity Interval Training on Cisplatin-Induced Renal Injury in Male Rats
چکیده انگلیسی مقاله Background: Cisplatin is a potent chemotherapeutic agent whose clinical use is limited by acute nephrotoxicity. This study aimed to evaluate the impact of high-intensity interval training (HIIT) on renal function and histology in cisplatin-treated rats. Materials and Methods: Thirty-two male Sprague-Dawley rats were assigned to four groups (n=8): Healthy Control (HC), Cisplatin Control (CC), HIIT-only (HIIT), and Cisplatin+HIIT (C-HIIT). The HIIT groups underwent an 8-week treadmill running protocol. Nephrotoxicity was induced by a single intraperitoneal cisplatin injection (5 mg/kg). Serum creatinine and urea were measured, and kidney tissues were analyzed using stereological methods. Results: Cisplatin administration significantly increased serum creatinine (CC: 1.28 ± 0.11 mg/dL vs. HC: 0.45 ± 0.08 mg/dL, p=0.001) and urea (CC: 112.5 ± 8.4 mg/dL vs. HC: 45.3 ± 5.1 mg/dL, p=0.001). HIIT in cisplatin-treated rats significantly reduced these levels (Creatinine: C-HIIT: 0.68 ± 0.09 mg/dL vs. CC, p=0.016; Urea: C-HIIT: 58.7 ± 6.9 mg/dL vs. CC, p=0.005). Stereological analysis revealed cisplatin-induced increases in kidney volume (p=0.003), glomerular volume (p=0.039), and cortical volume (p=0.02), which were significantly attenuated by HIIT (p<0.05 for all). Conclusion: An 8-week HIIT protocol significantly ameliorated cisplatin-induced renal dysfunction and histological damage in rats. These findings highlight the potential of HIIT as a non-pharmacological strategy to mitigate chemotherapy-related nephrotoxicity.
کلیدواژه‌های انگلیسی مقاله Cisplatin, High-Intensity Interval Training, Kidney Histology, Creatinine, Urea
نویسندگان مقاله | Mohammad Parastesh
Associate Professor of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran


| Abbas Parvaneh
MA, Department of Sport Physiology and Pathology, Faculty of Sport Sciences, Arak University, Arak, Iran


| Abbas Saremi
Professor of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran.


| Behzad Aria
Assistant Professor of Sports Physiology Department of Sport Sciences, Faculty of Psychology and Educational Sciences, Yazd University, Yazd, Iran.
نشانی اینترنتی http://rmm.mazums.ac.ir/browse.php?a_code=A-10-1352-3&slc_lang=en&sid=1
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