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Avicenna Journal of Phytomedicine، جلد ۱۵، شماره ۶، صفحات ۱۶۶۲-۱۶۷۶
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عنوان انگلیسی The efficacy of Cassia fistula on constipation in chronic kidney disease patients in comparison with lactulose: A randomized clinical trial
چکیده انگلیسی مقاله Objective: Chronic constipation (CC) is common in chronic kidney disease (CKD) patients. This study was performed to evaluate the efficacy of Cassia fistula syrup (CFS) on CC in CKD patients.Materials and Methods: This randomized clinical trial was conducted on CKD patients with CC referred to nephrology clinics of Babol University of Medical Sciences in 2022-23.They were examined by a nephrologist and 66 patients were randomly allocated into two groups, receiving CFS or lactulose, with the same dosage (30 ml/day) for 2 weeks. Patients were visited in the 1st, 2nd and 3rd weeks to evaluate clinical characteristics according to ROME IV criteria, quality of life (PAC-QOL), and laboratory factor levels. Data were analyzed by SPSS25 using intention to treat viewpoint and by applying the ANCOVA, Repeated measure analysis, T-test and Chi-square test.Results: In the CFS group, defecation frequency per week and daily (primary outcome) improved significantly compared to the lactulose group (p-Value=0.01).As secondary outcomes, the percent of straining, lumpy stools and stool hardness in the CFS group was significantly better than the lactulose (p <0.05). In the CFS group, blood urea nitrogen (BUN) (p-Value=0.045) and creatinine (Cr) (p =0.01) decreased after the intervention significantly. PAC-QOL showed significant improvements in subscales and total scores in the CFS group compared to the lactulose group (p<0.001).Conclusion: This is the first trial that evaluated CFS on CC in CKD patients, and monitored the changes in laboratory factors levels. CFS demonstrates greater efficacy than lactulose in managing CC among CKD patients. PAC-QOL was greatly better in CFS group rather than lactulose group.
کلیدواژه‌های انگلیسی مقاله Cassia fistula, Chronic constipation, chronic kidney disease, Persian Medicine, Lactulose
نویسندگان مقاله | Iman Jahanian
Student Research Committee, Babol University of Medical Sciences, Babol, Iran


| Roghayeh Akbari
Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran


| Hoda Shirafkan
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran


| Maedeh Rezghi
Traditional Medicine and History of Medical Sciences Research Center, Health, Research Institute, Babol University of Medical Sciences, Babol, Iran


| Seyyed Ali Mozaffarpur
Traditional medicine and history of medical sciences researh center, health research institute, Babol university of medical sciences, Babol, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_26012.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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