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Iranian Biomedical Journal، جلد ۲۹، شماره ۴، صفحات ۱۸۹-۲۰۵
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عنوان انگلیسی Transdermal Iontophoresis Insulin in Laboratory Animals: A Systematic Review
چکیده انگلیسی مقاله
Insulin therapy is essential for regulating glucose levels in diabetic patients. However, subcutaneous insulin injection, despite being a standard procedure, is invasive and often painful and can lead to complications such as skin damage and infections. These issues often result in poor patient compliance and inadequate glycemic control. Recently, transdermal insulin administration has been explored as an alternative to subcutaneous methods; however, no universally accepted protocol has been developed for its use. This systematic review aimed to evaluate the effect of iontophoresis on transdermal insulin administration in laboratory animals. Using the PICO search strategy and in accordance with PRISMA guidelines, relevant articles published from January 1980 to May 2025 were retrieved from Scopus, PubMed, ISI Web of Science, PEDro, Science Direct, and Google Scholar databases. The findings from these studies suggest that combining iontophoresis with physical enhancers of skin penetration can effectively regulate blood glucose levels while minimizing the risk of hypoglycemia.
کلیدواژه‌های انگلیسی مقاله Transdermal delivery, Insulin, Iontophoresis, Skin, Laboratory animals, Diabetes
نویسندگان مقاله | Zeinab Ahmadpour Emshi
Student Research Committee, Ph.D. Candidate of Physiotherapy, Department of Physiotherapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mohammad Mohsen Roostayi
Physiotherapy Research Center, Department of Physiotherapy, School of Rehabilitation, Shahid Beheshti Medical University, Tehran, Iran.


| Aliyeh Daryabor
Physiotherapy Research Center, Department of Physiotherapy, School of Rehabilitation, Shahid Beheshti University of Medical Science, Iran, Tehran.


| Maryam Niajalili
Student Research Committee, Ph.D. Candidate of Physiotherapy, Department of Physiotherapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Sedigheh Sadat Naimi
Physiotherapy Research Center, Department of Physiotherapy, School of Rehabilitation, Shahid Beheshti Medical University, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6321-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Related Fields
نوع مقاله منتشر شده سیتماتیک ریویو
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