این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Dermatology، جلد ۲۸، شماره ۳، صفحات ۱۸۱-۱۸۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Investigating lipid profile modifications in several forms of lichen planus
چکیده انگلیسی مقاله Background: Lichen planus (LP) is a chronic inflammatory mucocutaneous disorder increasingly associated with systemic metabolic abnormalities, particularly dyslipidemia. Emerging evidence suggests that chronic inflammation in LP may alter lipid metabolism, thereby contributing to an elevated cardiovascular risk profile. This study aimed to evaluate changes in lipid profiles across different clinical variants and durations of LP, with a focus on identifying patterns associated with disease distribution, severity, and metabolic risk.   Methods: A cross-sectional study was conducted over six months at Al-Kindy teaching hospital involving 64 adult patients clinically diagnosed with LP. Demographic data, disease characteristics, and lipid profiles—including total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL)—were collected. Patients were stratified according to LP subtype, BMI, and disease duration. Results: LP patients with a disease duration >12 months exhibited significantly elevated TC (213.92 ± 26.41 mg/dL) and TG (166.23 ± 30.78 mg/dL). A biphasic pattern in HDL was observed, with the lowest levels during 6–12 months of disease (P = 0.005). The oral and cutaneous subtype demonstrated the highest mean cholesterol, while the oral and genital subtype exhibited the highest triglycerides. Significant associations were found between BMI and LP subtype (P = 0.008), with obese patients showing a higher prevalence of multisite involvement. Conclusion: LP, particularly in its chronic and multisite forms, is associated with dysregulated lipid metabolism. These findings underscore the importance routine metabolic screening in LP patients to prevent long-term cardiovascular complications.  
کلیدواژه‌های انگلیسی مقاله Lipids,protein processing,post-translational,Lichen Planus
نویسندگان مقاله Samar Ahmed Jasim |
Department of Dermatology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Ethar Thaer Mustafa |
Collage of Medicine, Al Iraqiya University, Baghdad, Iraq

Fatin Ahmed Fakhry |
Hammurabi Medical College, University of Babylon, Babylon, Iraq

نشانی اینترنتی https://www.iranjd.ir/article_227026_c58ea6c8c4a0b243d8dccf392351f8a7.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات