این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Dermatology، جلد ۲۸، شماره ۳، صفحات ۱۴۶-۱۵۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Enhancing wound healing: the effects of vitamin C on fibroblasts, collagen, and epithelialization in an in vivo study
چکیده انگلیسی مقاله Background: Vitamin C is well recognized for its role in collagen synthesis and wound repair; however, its effects on critical healing parameters warrant further investigation. This study aimed to evaluate the impact of vitamin C on fibroblast count, collagen density, and epithelial thickness in Wistar rats with incisional wounds.
Methods: This experimental study investigated the effects of vitamin C on wound healing in Wistar rats with incisional wounds. The rats were divided into a control group and a treatment group, with the latter receiving daily subcutaneous injections of vitamin C (nine mg) for seven days. Histopathological analyses were performed on skin biopsies from the rats' backs using Hematoxylin-Eosin and Masson’s trichrome staining to assess fibroblast count, collagen density, and epithelial thickness. Data were analyzed using SPSS version 24.0, employing Mann-Whitney U tests for fibroblast counts and independent t-tests for collagen density and epithelial thickness. Pearson’s correlation coefficient was used to assess the relationship between fibroblast count and collagen density.
Results: Vitamin C treatment significantly increased fibroblast count by 28.08% (P = 0.018), collagen density by 25.75% (P = 0.013), and epithelial thickness by 34.07% (P = 0.001) compared to the control group. No significant correlation (P = 0.125) was observed between fibroblast count and collagen density.
Conclusion: Vitamin C can increase the number of fibroblasts, collagen density, and epithelial thickness in incision wounds in Wistar rats. These findings suggest that vitamin C may enhance wound healing outcomes; however, further research is necessary to explore the complex interactions among these factors.
 
کلیدواژه‌های انگلیسی مقاله Ascorbic acid,collagen,epithelial cells,Fibroblasts,wound healing
نویسندگان مقاله Hanna Mufliha |
Biomedical Science Postgraduate, Universitas YARSI, Jakarta, Indonesia

Harliansyah Harliansyah |
Biochemistry Departement, Medical Faculty, Universitas YARSI, Jakarta, Indonesia

Juniarti Juniarti |
Biochemistry Departement, Medical Faculty, Universitas YARSI, Jakarta, Indonesia

Ndaru Andri Damayanti |
Parasitology Department, Medical Faculty, Universitas YARSI, Jakarta, Indonesia

Nunung Ainur Rahmah |
Anatomical Pathology Department, Medical Faculty, Universitas YARSI, Jakarta, Indonesia

نشانی اینترنتی https://www.iranjd.ir/article_227021_024ee27c4c7e020558bbd0b15a3c757d.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات