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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۲۴، شماره ۹۵، صفحات ۴۵-۵۹
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عنوان انگلیسی Antidiabetic effects of <i>Morus alba</i> Linn leaf extract in a high-fat diet and streptozotocin-induced type 2 diabetic mouse model
چکیده انگلیسی مقاله
Background: The rising prevalence of diabetes mellitus underscores the need for safer therapeutic options, including natural products. Morus alba Linn leaf extract (MAE), a traditional remedy and the key component of the herbal product DIDALA, has been investigated for its potential antidiabetic properties. Objective: This study aimed to investigate the hypoglycemic and lipid-modulating effects of MAE in a type 2 diabetes (T2DM) experimental model induced by a high-fat diet (HFD) and streptozotocin (STZ) in mice. Methods: T2DM was induced in male Swiss mice by 8 weeks of an HFD followed by an intraperitoneal injection of STZ at 100 mg/kg. Diabetic mice were orally administered for 14 days with either a low dose MAE (0.8208 g/kg/day), a high dose MAE (2.4624 g/kg/day), or Gliclazide (80 mg/kg/day) as a positive control. Outcomes assessed included fasting blood glucose, lipid profiles (total cholesterol, LDL-cholesterol), liver and pancreatic malondialdehyde (MDA) as a marker of oxidative stress, and histological examination. Results: The low dose of MAE significantly reduced fasting blood glucose and improved lipid profile by lowering total cholesterol and LDL-cholesterol, with outcomes comparable to the Gliclazide group. It also reduced liver and pancreatic MDA levels, indicating decreased oxidative stress, and ameliorated histopathological alterations in the liver and pancreas. The high-dose MAE exerted less pronounced effects on glucose levels but still demonstrated some lipid and oxidative stress benefits. Conclusion: MAE, particularly at the lower dose, exhibits promising hypoglycemic and lipid-lowering effects in a HFD/STZ-induced T2DM mouse model, supporting its potential as a natural therapeutic candidate for diabetes management. Further studies should explore dose optimization, long-term efficacy, safety, and mechanisms of action.
کلیدواژه‌های انگلیسی مقاله Antioxidant activity, Diabetic mice, High-fat diet, Morus alba Linn, Streptozotocin
نویسندگان مقاله | Ha Thi Thu Nguyen
Department of Traditional Medicine, Hanoi Medical University, Hanoi, Vietnam


| Ngoc Kim Nguyen
Department of Traditional Medicine, Hanoi Medical University, Hanoi, Vietnam


| Hang Thi Thu Dinh
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam


| Quang Vinh Trinh
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam


| Quynh Thi Nhu Nguyen
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam


| Ha Thi Thanh Nguyen
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam


| Nam Vu
Department of Traditional Medicine, National Hospital of Traditional Medicine, Hanoi, Vietnam


| Nghia Trong Duong
Department of Traditional Medicine, National Hospital of Traditional Medicine, Hanoi, Vietnam


| Phong Xuan Pham
Department of Traditional Medicine, Military Institute of Traditional Medicine, Hanoi, Vietnam


| Van Anh Thi Pham
Department of Pharmacology, Hanoi Medical University, Hanoi, Vietnam
نشانی اینترنتی http://jmp.ir/browse.php?a_code=A-10-7058-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده فارماکوگنوزی و فارماسیوتیکس
نوع مقاله منتشر شده پژوهشی
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