این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۲۴، شماره ۹۵، صفحات ۳۵-۴۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی <i>In vitro</i> anti-leishmanial activity of <i>Boswellia sacra</i> gum resin extract on <i>Leishmania major</i> promastigotes
چکیده انگلیسی مقاله
Background: The adverse effects of traditional chemical treatments have driven interest in herbal compounds for leishmaniasis therapy. Objective: This study aimed to investigate the anti-leishmanial effect of Boswellia sacra gum resin extract on the survival of Leishmania major promastigotes. Methods: Leishmania major strain (MHOM/IR/75/ER) was adjusted to 2 × 105 parasites per well. Promastigotes were exposed to a range of B. sacra gum resin extract concentrations (15, 25, 50, 70, 100, 200, 400, 800, 1600, and 3200 µg/ml) for 24 hours. Viability and cytotoxic effects were assessed using the MTT assay (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) with absorbance measured at 450 nm. Result: The B. sacra gum resin extract reduced promastigotes viability at various concentrations, with statistically significant effects observed at 800, 1600, and 3200 µg/mL (P ≤ 0.05). Cytotoxic effects at 1600 and 3200 µg/mL were significantly greater than those at 15, 25, and 50 µg/mL (P ≤ 0.01). Conclusion: Based on the in vitro anti-leishmanial activity observed, Boswellia sacra resin extract warrants further investigation as a potential agent against cutaneous leishmaniasis. Future in vivo studies are recommended to evaluate efficacy and safety.
کلیدواژه‌های انگلیسی مقاله Boswellia sacra resin, Leishmania major, Cytotoxicity, Viability, In vitro
نویسندگان مقاله | Sahar Hamoonnavard
Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran


| Hossein Rezvan
Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran


| Fatemeh Behdarvand
Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran


| Behnaz Bazargani-Gilani
Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran


| Mahshid Mousavi
Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran
نشانی اینترنتی http://jmp.ir/browse.php?a_code=A-10-6941-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده گیاهان دارویی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات