| چکیده انگلیسی مقاله |
Introduction: Wound healing is crucial for improving patients' quality of life, especially in conditions like diabetes, burns, and surgical wounds. Fiber-based dressings with antioxidant and antibacterial agents, natural polymers, and zeolite nanoparticles accelerate healing and regeneration. The aim of this study was to design and fabricate nanofiber scaffolds based on polyvinyl alcohol (PVA), chitosan, and tragacanth gum, containing zeolite nanoparticles as wound dressings.
Materials & Methods: MT-type zeolite crystals with molecular dimensions and sizes ranging from approximately 10 to 20 nm were synthesized via a low-temperature hydrothermal method using colloidal precursors, without the need for organic templates. The physical and structural properties of the synthesized nanoparticles, including Fourier-transform infrared spectroscopy (FTIR) analysis, particle size distribution, and surface zeta potential, were characterized. Subsequently, nanofibers based on polyvinyl alcohol (PVA), chitosan (CS), and tragacanth gum (TG), incorporating the zeolite nanoparticles, were fabricated through electrospinning. The nanofibers were thoroughly evaluated for their physicochemical, structural, mechanical, cellular toxicity, antioxidant activity, and antibacterial performance.
Results: The characterization tests demonstrated that the nanofiber wound dressings containing zeolite nanoparticles exhibited superior properties compared to the control group without nanoparticles. These nanofibers showed enhanced performance in terms of morphology, fiber diameter, mechanical strength, swelling ratio, degradation rate, porosity, antioxidant activity, cellular biocompatibility, and antibacterial efficacy.
Conclusion: The results of this study demonstrated that nanofibers composed of polyvinyl alcohol (PVA), chitosan (CS), and tragacanth (TG) possess optimal physical and biological properties, creating a suitable environment to accelerate the wound healing process. The study suggests that the incorporation of EMT-type zeolite nanoparticles in PVA/CS/TG/EMT-ZIF nanofibers can enhance their antioxidant and antibacterial properties, making them promising for biomedical engineering applications. |
| نویسندگان مقاله |
مهناز محمدپور | Mahnaz Mohammadpour
Dept of chemistry, Faculty of Sciences, Tarbiat Modares University, Tehran, Iran
گروه شیمی، دانشکده علوم پایه، دانشگاه تربیت مدرس، تهران، ایران
حامد قنبری | Hamed Ghanbari
Dept of Organic Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran
گروه شیمی آلی، دانشکده شیمی، دانشگاه رازی، کرمانشاه، ایران
ژیلا ایزدی | Zhila Izadi
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
مرکز تحقیقات علوم دارویی، پژوهشکده سلامت، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران
هانیه رضایی | Hanieh Rezaee
Pharmaceutical Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران
حسین درخشان خواه | Hossein Derakhshankhah
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
مرکز تحقیقات علوم دارویی، پژوهشکده سلامت، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران
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