این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Addiction and Health، جلد ۱۷، شماره ۱، صفحات ۱-۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Brain-Derived Neurotrophic Factor Gene Polymorphism, Craving, and Stress Among Alcohol-Dependent Patients: A Preliminary Cross-sectional Study from India
چکیده انگلیسی مقاله Background: Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal plasticity and survival. The BDNF gene Val66Met polymorphism is hypothesized to be linked with alcohol dependence syndrome (ADS). We studied the relationship between the BDNF Val66Met polymorphism and the clinical features of ADS, including severity, craving, and perceived stress among alcohol-dependent patients.
Methods: In this cross-sectional study on treatment-seeking north Indian male ADS patients aged 18 to 60 years, alcohol dependence severity (Severity of Alcohol Dependence Questionnaire, SADQ), craving (obsessive compulsive drinking scale), and perceived stress (perceived stress scale-4) were measured. The genetic analysis for calculating the BDNF Val66Met allele frequency was carried out using TaqMan assays. Statistical analysis was done using SPSS Version 26.
Findings: The participants’ mean age (SD) (n = 80) was 37 ± 8.52 years. Half of the participants had tobacco dependence, too. Almost half of the participants showed alcohol dependence with mild severity. The mean OCDS and PSS-4 scores were 26.08 ± 9.34 and 9.08 ± 2.4, respectively. The allelic frequency of the Val and Met alleles were 73.1% and 26.9%, respectively. Among the Met allele carriers, the OCDS (P = 0.02) and PSS-4 scores (P = 0.03) were significantly higher than observed in the Val group patients.
Conclusion: The study concludes that BDNF gene Val66Met polymorphism could impact clinical variables such as craving and perceived stress in alcohol-dependent subjects. It merits the use of genetic analysis in determining the course of clinical maintenance of alcohol-dependent patients.
کلیدواژه‌های انگلیسی مقاله Alcohol Dependence,Brain-derived neurotrophic factor,craving
نویسندگان مقاله Shubha Bagri |
Department of Psychiatry, All India Institute of Medical Sciences, Delhi, India

RIZWANA QURAISHI |
National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, Delhi, India

Ram Kumar |
National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, Delhi, India

Shalini Singh |
National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, Delhi, India

Atul Ambekar |
National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, Delhi, India

نشانی اینترنتی https://ahj.kmu.ac.ir/article_92735_78a6b8b830e7279b600c5b8386b145ec.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات