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Veterinary Research Forum، جلد ۱۶، شماره ۹، صفحات ۴۹۹-۵۰۵
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عنوان انگلیسی Ameliorative effects of betaine on cisplatin-induced cardiotoxicity in rats through anti-inflammatory pathways
چکیده انگلیسی مقاله Cisplatin (CS) is a broad-spectrum chemotherapeutic agent that causes serious adverse effects, such as cardiotoxicity, despite its potent anti-tumor efficacy. This study aimed to evaluate the cardioprotective effects of betaine in rats exposed to repeated low-dose CS administration using histopathological and immunohistochemical methods. Forty female Wistar albino rats were divided into four groups, including control, betaine, CS, and CS + betaine. Betaine (250 mg kg-1) was administered orally on a daily basis for four weeks, while CS (8.00 mg kg-1) was administered intraperitoneally once a week for the same duration. Cardiomyocytes were then examined using histopathological and immunohistochemical methods. The data were analyzed using one-way analysis of variance and Tukey tests. Histopathological analysis revealed cardiomyocyte disorganization, myofibril loss, and increased eosinophilia in the CS group. Betaine treatment partially prevented CS-induced histological damage, contributing to the cardiac muscle structure preservation. Immunohistochemical analyses demonstrated a significant increase in transforming growth factor-beta and interferon gamma expressions in the CS group, whereas betaine administration reduced transforming growth factor-beta levels. Interleukin 6 expression was lower in the CS + betaine group compared to the CS group. No significant differences were observed between groups regarding Interleukin -1β expression. These findings suggest that betaine may have protective effects against CS-induced cardiotoxicity. Its anti-inflammatory properties appear to mitigate cardiomyocyte damage.
کلیدواژه‌های انگلیسی مقاله Betaine,Cardiotoxicity,cisplatin,Immunohistopathology,Rat
نویسندگان مقاله Menekşe Ülger |
Department of Histology and Embryology, Faculty of Medicine, Erciyes University, Kayseri, Türkiye

نشانی اینترنتی https://vrf.iranjournals.ir/article_728643_b73b2eddeda05b7978cd1706beaf02e7.pdf
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