Objective: The purpose of this study was to determine the effectiveness of relaxation therapy based on virtual reality on perceived stress, resilience and substance temptation in people with substance use disorder referring to Andimeshk residential centers..Method:The research method was semi-experimental with a pre-test-post-test design with a control group. The statistical population of this research included all men with substance use disorder who referred to the residential centers of Andimeshk in 1403, from which 30 people were selected by available sampling method and randomly divided into two experimental groups(15 people, sedation treatment based on virtual reality) and a control group(15 people who did not receive treatment) were included. The participants of both groups completed the questionnaires of perceived stress by Cohen et al.(1983), resilience by Connor and Davidson(2003), and material temptation by Franken et al.(2002) in the pre-test and post-test stages.Relaxation therapy based on virtual reality was performed on the experimental group in 8 sessions of 60 minutes with the frequency of one session per week. The data were analyzed by multivariate and univariate analysis of covariance. Results: The findings showed that there was a significant difference between the experimental and control groups in terms of perceived stress, resilience, and substance temptation. In other words, virtual reality-based relaxation therapy reduced perceived stress, increased resilience, and reduced substance temptation in the experimental group. Conclusion: relaxation therapy based on virtual reality using techniques such as breathing exercises with voice commands, lighting and color spectrum; muscle relaxation exercise; Calm music along with immersion in the forest and the beach at the user's choice, spiritual relaxation and restorative experiences (joy of life and healing) in the context of virtual reality can be used as an effective therapy to reduce perceived stress, increase resilience and also Reducing drug temptation in men with substance use disorder.