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Research in Pharmaceutical Sciences، جلد ۲۰، شماره ۴، صفحات ۴۶۹-۴۸۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Octreotide and direct/indirect lung injury |
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| چکیده انگلیسی مقاله |
Background and purpose: Lung injury is one of the most important diseases, which is accompanied by hypoxemia, organ failure, and a high mortality rate. There are several symptoms and causes of lung injuries. In the past years, special attention has been given to investigating the pathophysiology and the treatment of this disease. Octreotide, as an anti-inflammatory, anti-secretory, tissue-repairing, and anti-fibrotic drug, has been considered and administered for the treatment of lung injury. This review article considered the pharmacological effects of octreotide on physiopathological conditions in patients or animal models that have direct or indirect lung injury. Search strategy and findings : Keywords including “octreotide” OR “sandostatin” AND “lung injury” OR “ARDS” OR “respiratory distress” OR “lung fibrosis” were searched in the database of PubMed, and 44 articles were found. According to the direct or indirect lung injury, the articles were classified. Conclusion : It appears that octreotide is a protective drug for the treatment of direct and indirect lung injuries, exhibiting anti-inflammatory, anti-hypersecretory, anti-fibrotic, and anti-neutrophil permeability effects, while also increasing endogenous antioxidants. However, there is still room for extensive research to fully clarify the effectiveness of octreotide for direct or indirect lung injury. |
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| کلیدواژه‌های انگلیسی مقاله |
Acute respiratory distress syndrome,Lung fibrosis,Lung injury,Octreotide. |
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| نویسندگان مقاله |
| Ghasem Zarei
Department of Physiology, Medical School, Isfahan University of Medical Sciences, I.R. Iran.
| Zahra Pezeshki
Department of Physiology, Medical School, Isfahan University of Medical Sciences, I.R. Iran.
| Samira Choopani
Department of Physiology, Medical School, Isfahan University of Medical Sciences, I.R. Iran.
Water and Electrolytes Research Center, Isfahan University of Medical Sciences, I.R. Iran.
| Mehdi Nematbakhsh
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| نشانی اینترنتی |
http://rps.mui.ac.ir/index.php/jrps/article/view/2321 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Review Article |
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