|
|
Medical Laboratory Journal، جلد ۱۹، شماره ۴، صفحات ۰-۰
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Evaluation of red cell alloantibodies in thalassemia major patients referred to blood transfusion center of Golestan province, Iran |
|
| چکیده انگلیسی مقاله |
Background: One of the major complications in thalassemia patients is alloimmunization, which is antibody production by the patient against transfused RBCs (red blood cells). In the present study, the frequency of alloantibodies in thalassemia patients was investigated.
Materials and Methods: In this cross-sectional retrospective study, the study was performed on ninety nine multi-transfused thalassemia patients, antibody screening test was carried out using three cell-panel. Positive patients were followed up for antibody identification using 11-cell panel. The information was finally analyzed using SPSS software version 16.0.
Results: Out of ninety-nine cases, 53 were female (53.53 %) and 46 male (46.46 %). The patient’s age mean was 29.22±10.46 years with 2 to 61 years age range. Only 5.05% (N=5) had developed alloantibodies. The most common alloantibodies were Anti-D, Anti-E, Anti-c and Anti-K. No significant correlation was seen between the presence of alloantibody and age, sex, blood type and spleen condition.
Conclusion: Antibody production against RBC antigens is a common problem in multi-transfused thalassemia patients. Compatibility between antigens of Kell and Rh blood group systems in donors and recipients can be one of the useful ways to prevent alloimmunization of blood recipients and the production of unexpected antibodies against donor’s red blood cells. |
|
| کلیدواژه‌های انگلیسی مقاله |
Alloantibody, Thalassemia, Blood transfusion |
|
| نویسندگان مقاله |
| sadegh baniaghil
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Gorgan, Iran
| fardin balochi
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
| ereste kazak
, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Gorgan, Iran
|
|
| نشانی اینترنتی |
http://mlj.goums.ac.ir/browse.php?a_code=A-10-1361-2&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
علوم آزمایشگاهی |
| نوع مقاله منتشر شده |
Research Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|