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Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۴، شماره ۸، صفحات ۲۰۲۸-۲۰۴۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Molecularly Imprinted Polymers with 3-Hydroxybutyrate Acid as a Template for Diabetic Ketoacidosis: Synthesis, Characterization, and Molecular Adsorption Investigations |
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| چکیده انگلیسی مقاله |
Diabetic ketoacidosis (DKA) is a serious complication of diabetes, more common in type 1 diabetes, but it can also occur in type 2 diabetes. It involves high blood glucose, dehydration, and acidic ketone build-up, with 3-hydroxybutyrate acid (3-HB) being a primary ketone indicating insulin deficiency. Monitoring 3-HB is vital for diagnosing and managing DKA. This study aimed to synthesize molecularly imprinted polymers (MIPs) using 3-hydroxybutyrate acid as a template, creating a selective sorbent that could serve as a cost-effective and efficient alternative to conventional diagnostic tools for diabetic ketoacidosis (DKA). The MIPs were characterized using Scanning Electron Microscopy (SEM) and Fourier Transform InfraRed (FT-IR) spectroscopy to confirm their morphology, chemical structure, and presence of imprinted sites specific to 3-hydroxy butyrate (3HB). Batch rebinding and isotherm adsorption profiles of MIP and NIP were evaluated using the batch method in ethanol at a concentration of 20-60 ppm. The FT-IR spectra of NIP01, MIP01, and MIP03 were analyzed to compare their spectral absorbance profiles and the types of vibration observed in their different compositions. The results demonstrated a significant difference in the batch rebinding and adsorption profiles between Non-Imprinted Polymers (NIPs) and MIP under the 3HB condition, with MIP04 showing consistently higher performance, achieving up to 93.12% at 20 ppm, and maintaining strong adsorption at higher concentrations, with 91.48% at 50 ppm and 90.81% at 60 ppm. These findings confirmed the superior performance of MIPs, particularly MIP04, in selectively capturing 3HB molecules, highlighting the significant advantage of molecular imprinting in enhancing the polymer's adsorption efficiency and selectivity. |
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| کلیدواژه‌های انگلیسی مقاله |
3-hydroxybutyrate acid,Diabetic ketoacidosis,FTIR,Itaconic acid,MIP,SEM |
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| نویسندگان مقاله |
Aiyi Asnawi |
Department of Pharmacochemistry, Faculty of Pharmacy, Universitas Bhakti Kencana, Jl. Soekarno-Hatta No. 754, Bandung 40617, INDONESIA
Hestiana Pratiwi |
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang km. 21, Jatinangor 45363, INDONESIA
Ellin Febrina |
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Bhakti Kencana, Jl. Soekarno-Hatta No. 754, Bandung 40617, INDONESIA
Widhya Aligita |
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Bhakti Kencana, Jl. Soekarno-Hatta No. 754, Bandung 40617, Indonesia.
La Ode Aman |
Department of Pharmacy, Universitas Negeri Gorontalo, Jl. Jend. Sudirman No.6, Dulalowo Tim., Kec. Kota Tengah, Kota Gorontalo, Gorontalo 96128, INDONESIA
Fachrul Razi |
Chemical Engineering Department, Universitas Syiah Kuala, Jl. Tgk. Syech Abdul Rauf No. 7, Darussalam-Banda Aceh 23111, INDONESIA
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| نشانی اینترنتی |
https://ijcce.ac.ir/article_725473_dca578fafc4629c09e46d9e36c36c4ab.pdf |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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