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Avicenna Journal of Phytomedicine، جلد ۱۵، شماره ۵، صفحات ۱۴۲۴-۱۴۳۷
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Effect of a Persian medicine formula, Glasthma, on lung function and intestinal permeability in Asthma: A triple-blind randomized controlled trial
چکیده انگلیسی مقاله Objective: This study aimed to evaluate Glasthma, a Persian medicine herbal formulation for its efficacy and safety in managing asthma symptoms and modulating intestinal permeability.Materials and Methods: Forty randomly assigned asthma patients received Glasthma syrup (n=20) or a placebo (n=20) twice daily for 4 weeks. Respiratory symptoms, pulmonary function tests, and 5-hour urine lactulose to mannitol ratio were assessed at baseline and after 4 weeks.Results: Glasthma group exhibited significant improvements in clinical and paraclinical scores, including asthma control test (p<0.001), asthma control questionnaire 7 (p<0.007), Forced Expiratory Volume in the First Second (p<0.001), and Maximal Mid-Expiratory Flow 25-75 (p<0.002) compared to the placebo group. Lactulose and mannitol levels significantly decreased in the Glasthma group (p<0.028 and p<0.0000, respectively), with no significant changes in the ratio. No serious adverse effects were observed.Conclusion: These findings suggest that Glasthma formulation may effectively improve asthma symptoms and regulate the gut-lung axis.
کلیدواژه‌های انگلیسی مقاله Asthma, Intestinal permeability, Traditional Persian medicine Phytotherapy
نویسندگان مقاله | Alireza Derakhshan
School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| majid mirsadraee
3. Majid Mirsadraee, Department of Internal Medicine, Faculty of Medicine, Islamic Azad University-Mashhad Branch, Mashhad, Iran. ORCID ID:0000-0003-3420-9438. .


| Amir-Mohammad-Hashem Asnaashari
COPD Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ORCID ID: 0000-0003- 2960-7132.


| Roshanak Salari
Department of Pharmaceutical Sciences in Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Majid Khadem Rezaiyan
Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, iran


| shahin saeidinejat
Department of Traditional Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Shima Jalali
Medical student , Mashhad University of Medical Sciences, Mashhad, Iran. ORCID ID: Medical student , Mashhad University of Medical Sciences, Mashhad, Iran. ORCID ID: 0000-0002-0696-2564. Shimajalali1374@gmail.com .


| Shabnam Jalali
Medical student , Mashhad University of Medical Sciences, Mashhad, Iran. ORCID ID: 0000-0002-9093-0660.


| Shadi Ghaffari
Department of biology, Islamic Azad University- Damghan Branch,. 0000-0002-9176-8650
نشانی اینترنتی https://ajp.mums.ac.ir/article_25579.html
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نوع مقاله منتشر شده Original Research Article
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