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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۱۰، صفحات ۱۳۷۲-۱۳۸۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Expressions of apoptotic protein and gene following sulfur mustard-induced acute pulmonary injuries in rats
چکیده انگلیسی مقاله Objective(s): Pathomechanisms of sulfur mustard (SM) are not fully understood, and no specific medical countermeasures exist to prevent SM-induced pulmonary injury. This study aimed to evaluate the apoptosis following SM-induced acute pulmonary injury.Materials and Methods: Acute pulmonary injury models were established using SM at an equivalent toxicity dose (1 LD50), administered via intraperitoneal injection or intratracheal instillation. Protein expression levels and mRNA expressions of apoptosis-related markers, including cellular inhibitor of apoptosis proteins-1 and -2 (cIAP-1, cIAP-2), Fas, Bcl-2-associated death promoter (Bad), second mitochondria-derived activator of caspases (Smac), and survivin (BIRC5), were analyzed using immunohistochemistry and polymerase chain reaction. Results: The intraperitoneal SM group exhibited significantly higher levels of apoptotic cells in the alveolar septa and increased protein and mRNA expression of cIAP-1, cIAP-2, Fas, Bad, Smac, and BIRC5 compared to the intratracheal SM group. These changes displayed a time-dependent increase in both protein and gene expression levels. Conclusion: SM-induced pulmonary injury involves both extrinsic (Fas, cIAP-1, cIAP-2) and intrinsic (Bad, Smac) pathways as well as caspase-dependent pathways (BIRC5). These findings provide valuable insights into the underlying mechanisms of SM toxicity and may facilitate the development of targeted therapeutic strategies.
کلیدواژه‌های انگلیسی مقاله Animals, Apoptosis, immunohistochemistry, Lung injury, Mustard Gas, Polymerase chain reaction
نویسندگان مقاله | Tao Liu
Department of Respiration, the 80th Group Army Hospital of People’s Liberation Army, Weifang, 261021, China


| Jingtong Li
Department of Respiration, the 80th Group Army Hospital of People’s Liberation Army, Weifang, 261021, China


| Xiaoxuan Hu
Department of Pulmonary and Critical Care Medicine, Weifang No. 2 People’s Hospital, Weifang Respiratory Disease Hospital, Weifang, 261041, China|State Key Laboratory of Antitoxic Drugs and Toxicology, Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing, 100850, China


| Jinyuan Tang
Department of Respiration, the 80th Group Army Hospital of People’s Liberation Army, Weifang, 261021, China


| Yuxu Zhong
State Key Laboratory of Antitoxic Drugs and Toxicology, Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing, 100850, China


| Xin Shu
Department of Dermatology, The Third Medical Center of Chinese PLA General Hospital, Beijing, 100039, China


| Xiao-ji Zhu
Department of Respiration, the 80th Group Army Hospital of People’s Liberation Army, Weifang, 261021, China
نشانی اینترنتی https://ijbms.mums.ac.ir/article_26322.html
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