In this research, drinking water quality was investigated using acceptability, health, and nutrition-based indicators from 2010 to 2022 in Shiraz City (Fars province). Magnesium, fluoride, and calcium play a significant role in the contribution of drinking water in Shiraz City to the intake of dietary minerals. The acceptability water quality index (AWQI), health-based water quality index (HWQI), and drinking water quality index (DWQI) rankings in Shiraz City are excellent, but the average drinking water nutritional quality index (DWNQI) of Shiraz City is 77.52 ± 5.47, which falls within the good ranking. Therefore, while the conventional water quality indices (AWQI, HWQI, and DWQI) are excellent, the DWNQI index does not achieve an excellent rating, due to the inclusion of the nutritional value of water in the DWNQI index. In general, the trend of AWQI, HWQI, DWQI, and DWNQI over thirteen years in Shiraz City shows that the conventional drinking water quality indices (AWQI, HWQI, and DWQI) do not provide an accurate picture of the assessment of drinking water quality in many cases, as they do not consider the nutritional role of water. For this reason, water is sometimes treated more than necessary. Therefore, it is essential to revise the interpretation of drinking water quality using the DWNQI index to gain a comprehensive picture of drinking water quality.