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Medical Laboratory Journal، جلد ۱۹، شماره ۳، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
EVALUATION OF NEUTROPHILIC CD64 IN ADULT SEPSIS AS A NOVEL DIAGNOSTIC MARKER |
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| چکیده انگلیسی مقاله |
Background & objectives: Sepsis is one of the most common cause of mortality among patients who are critically ill and in Intensive Care Units(ICU). Bacterial infection or sepsis leads to an increase in Neutrophilic CD64(nCD64) expression on activated polymorphonuclear leukocytes(PMNs). Early diagnosing of sepsis is very important in order to start timely and specific treatment. The availability of a rapid laboratory test with high specificity for sepsis in adult patients could aid in therapeutic decision making and reduce unnecessary antibiotic use.
Methods: Sepsis patients diagnosed as per sepsis-3 definition were included in this study. 2 ml blood sample was collected in EDTA & plain vial each for evaluation of nCD64, Procalcitonin(PCT) & high sensitivity C-reactive protein(hS-CRP). The samples were run on Flow cytometer, Nephelometer and Chemiluminescence for nCD64, hS-CRP and PCT respectively.
Result: The Positive Predictive Value(PPV) of nCD64 for prediction of sepsis was 92.68% and the Negative Predictive value(NPV) was 94.87%. Receiver operating curve(ROC) was plotted for indicating the diagnostic accuracy of nCD64(≥1.8), hS-CRP(≥3 mg/L) and PCT(≥0.4 ng/mL). Area under the curve(AUC) for nCD64 was highest[0.938(95%CI=0.876-0.999)] followed by hS-CRP[0.888(95%CI=0.807-0.968)] and PCT [0.850(95%CI =0.759-0.941)].
Conclusion: These findings are suggestive of the possibility that nCD64 determination was a useful tool for diagnosing infection in patients with septic syndrome, with a performance superior to that of hS-CRP and PCT.
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| کلیدواژه‌های انگلیسی مقاله |
nCD64, PCT, hS-CRP, Adult sepsis, Novel diagnostic marker |
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| نویسندگان مقاله |
| ANURADHA SAINI
VARDHMAN MAHAVIR MEDICAL COLLEGE, NEW DELHI
| ANJALI SHARMA
VARDHMAN MAHAVIR MEDICAL COLLEGE, NEW DELHI
| MUKUL SINGH
VARDHMAN MAHAVIR MEDICAL COLLEGE, NEW DELHI
| SHAILY GOYAL
VARDHMAN MAHAVIR MEDICAL COLLEGE, NEW DELHI
| MANINDER NARANG
VARDHMAN MAHAVIR MEDICAL COLLEGE, NEW DELHI
| SUNIL RANGA
Department of Pathology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.
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| نشانی اینترنتی |
http://mlj.goums.ac.ir/browse.php?a_code=A-10-1608-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ایمنی شناسی |
| نوع مقاله منتشر شده |
تحقیقی |
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