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Medical Laboratory Journal، جلد ۱۹، شماره ۳، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The evaluation of the effect of periodic resistance training along with vitamin D3 consumption and mesenchymal stem cell transplantation on cortical TNF-β level in streptozotocin-induced diabetic rats |
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| چکیده انگلیسی مقاله |
Background and objectives: Inflammation plays a major role in the development and progression of diabetes. Vitamin D deficiency and physical inactivity can also increase the risk of developing type 2 diabetes. Combined therapeutic strategies are promising approaches for the treatment and prevention of diabetes. The aim of this study was to investigate effects of resistance training, vitamin D3 supplementation and adipose-derived mesenchymal stem cell (MSC) transplantation on tumor necrosis factor-beta level in the cerebral cortex of diabetic rats.
Methods: Eighty male Wistar rats (weighing 290±19 g) were randomly divided in to 10 groups: healthy control, sham, diabetes, training, vitamin D, MSC, training+vitamin D, MSC+training, MSC+vitamin D and training+MSC+vitamin D. Training groups were subjected to a resistance training program on ladder. MSC groups received 1.5 × 106 MSCs and vitamin D supplementation groups received 1 microgram/kilogram vitamin D3 eight times. Cortical TNF-β level and fasting serum glucose levels were measured.
Results: After 6 weeks, the combination of resistance training with vitamin D3 supplementation and MSC transplantation (P=0.018) as well as the combination of resistance training with MSCs (P=0.024) significantly reduced diabetes-induced elevation of TNF-β level.
Conclusion: Resistance training with appropriate intensity, duration and recovery between exercise sessions, combined with MSC transplantation and vitamin D3 supplementation has profound anti-inflammatory effects on the cerebral cortex tissue of diabetic rats. This type of intervention, especially the transplantation of MSCs, may be a promising protective strategy against some complications of diabetes.
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| کلیدواژه‌های انگلیسی مقاله |
Resistance training, Vitamin D, Stem cell, Diabetes, Inflammation |
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| نویسندگان مقاله |
| Seyed Abdollah Hashemvarzi
Department of Exercise Physiology, Sar.C., Islamic Azad University, Sari, Iran
| Behrooz Mohammadnezhad
Department of Exercise Physiology, Sar.C., Islamic Azad University, Sari, Iran
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| نشانی اینترنتی |
http://mlj.goums.ac.ir/browse.php?a_code=A-10-404-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
ایمنی شناسی |
| نوع مقاله منتشر شده |
Research Article |
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