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Archives of Breast Cancer، جلد ۱۲، شماره ۳، صفحات ۳۳۴-۳۴۲
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عنوان انگلیسی Circulating Cell-Free DNA as a Potential Biomarker in Breast Cancer: Roles of CA15-3 in breast cancer
چکیده انگلیسی مقاله Background: Breast cancer remains the leading cause of mortality among middle-aged women in the west. Research has shown that cancer patients exhibit significantly elevated levels of circulating cell-free DNA (cfDNA), largely due to the presence of circulating tumor DNA (ctDNA). This study aimed to assess cfDNA concentrations in three groups: newly diagnosed breast cancer patients, individuals with benign breast conditions, and healthy participants. Additionally, it sought to explore cfDNA's potential as a noninvasive biomarker for early breast cancer detection. The study also compared cfDNA's diagnostic sensitivity with that of CA15-3, a traditional tumor marker, to evaluate its effectiveness in breast cancer diagnosis. Methods: This is a case-control study involving 28 patients with primary breast cancer, 15 patients with benign breast tumors, and 10 healthy individuals. The plasma concentration of circulating cfDNA was measured using real-time PCR. Results: The study showed a significant difference in the circulating cfDNA levels between the cancer group (mean ± SD = 77.76 ± 152.76 ng/mL) and both benign and control groups (mean ± SD = 0.31 ± 0.87 ng/mL and 1.03 ± 1.46 ng/mL, respectively), with P < 0.001 for both. There was a statistically significant association between elevated levels of circulating cfDNA and advanced cancer stages, with P < 0.001. Additionally, circulating cfDNA demonstrated 100% sensitivity compared to CA15-3, which had a sensitivity of 25%. Conclusion: This study found that plasma levels of cfDNA were considerably higher in cancer patients than in the benign and control groups, with cfDNA levels raised significantly when cancer progressed to advanced stages.
کلیدواژه‌های انگلیسی مقاله Biomarkers, tumor, breast cancer diagnosis, cell-free nucleic acids, breast neoplasm
نویسندگان مقاله
نشانی اینترنتی https://archbreastcancer.com/index.php/abc/article/view/1107
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کد مقاله (doi) 10.32768/abc.8925869708050
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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