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Archives of Breast Cancer، جلد ۱۲، شماره ۳، صفحات ۳۰۳-۳۱۰
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عنوان انگلیسی Efficacy of Cancer Antigen 15-3, Trefoil Factor-3, and Human Epididymis Protein-4 in the Diagnosis of Breast Cancer: Cancer antigens in BC
چکیده انگلیسی مقاله Background: Breast cancer (BC) is a significant global health concern, and delayed or frequently inadequate diagnosis has led to fatalities in many women. Consequently, research is needed to evaluate novel biomarkers for BC detection and monitoring. The current study aimed to assess the effectiveness of Cancer Antigen 15-3 (CA15-3), Trefoil Factor-3 (TFF3), and Human Epididymis Protein-4 (HE4) in diagnosing and monitoring BC. Methods: The present case-control study recruited 72 women with BC, who were categorized into pre-treatment (n=15) and post-treatment with chemotherapy involving anthracycline, cyclophosphamide, and docetaxel (n=57). Additionally, 15 healthy women served as controls. Serum levels of these biomarkers were measured at Al-Sadder Teaching Hospital in Iraq, using COBAS Integra 400 Plus for CA15-3 and enzyme-linked immunosorbent assay (ELISA) for TFF3 and HE4. Results: Statistical analysis revealed significantly elevated CA15-3 and TFF3 levels in pre-treatment and post-treatment groups compared to controls (P<0.0001), with CA15-3 increasing from 10.27±2.89 U/mL (controls) to 63.3±19.24 U/mL (pre-treatment) and TFF3 from 4.73±0.97 pg/mL to 1811.0±155 pg/mL. The HE4 levels remained consistent across all groups (P=0.409). Conclusion: These results support the use of CA15-3 and TFF3 as complementary biomarkers for BC management, particularly in tracking treatment response and disease recurrence.
کلیدواژه‌های انگلیسی مقاله breast neoplasm, Cancer Antigen 15-3, Human Epididymis Protein-4, Trefoil Factor-3
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نشانی اینترنتی https://archbreastcancer.com/index.php/abc/article/view/1093
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کد مقاله (doi) 10.32768/abc.8773311177538
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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