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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۹، صفحات ۱۱۲۹-۱۱۳۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Ketone body, as an emerging modulator of metabolic reprogramming and epigenetics in breast cancer |
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| چکیده انگلیسی مقاله |
The metabolic profile of cancer cells, notably their reliance on glucose as a primary energy source for proliferation, sets them apart from normal cells. This metabolic dependency may significantly affect their invasive potential when an adequate glucose supply is available. Moreover, emerging evidence underscores the critical role of metabolism in determining the epigenetic landscape of cells. To limit the glucose supply and alter cancer cell metabolism, researchers have investigated ketogenic diets as an alternative energy source for cancer cells and providing a promising strategy to combat cancers. However, controversial findings in the literature suggest a direct relationship between the use of ketone bodies in cancer cells and the augmentation of invasiveness. Additionally, studies indicate that using ketone bodies as an energy source can influence the epigenetic patterns of tumor cells. Breast cancer cells show a unique metabolism by which the cancer cells adapt to various conditions. This paper aims to review the metabolic characteristics of breast tumors, focusing on the ketone body metabolism in this cancer and the complex interplay between ketone bodies and the epigenetic changes in this cancer. |
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| کلیدواژه‌های انگلیسی مقاله |
Breast Cancer, Epigenetics, Histone Modifications, Ketone bodies, Metabolism |
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| نویسندگان مقاله |
| Fatemeh Mehdikhani
Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Sadegh Rajabi
Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Maryam Mohammadlou
Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran
| Marc Maresca
Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, 13013 Marseille, France
| Rasoul Baharlou
Department of Immunology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
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| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_26150.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Review Article |
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