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Iranian Journal of Nuclear Medicine، جلد ۳۳، شماره ۲، صفحات ۱۴۱-۱۵۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Assessment of radiation-induced thyroid gland damage in breast cancer patients: A systematic review |
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| چکیده انگلیسی مقاله |
Introduction: The thyroid gland is known as particularly sensitive to radiation therapy. Numerous research studies have indicated that radiation treatment for breast cancer can expose this organ to significant levels of radiation. Hence, the primary objective of this study is to investigate the thyroid gland as a potential organ at risk following radiation therapy for breast cancer, utilizing a systematic review methodology.
Methods: In this systematic review, two independent reviewers conducted a comprehensive search identify relevant studies. The search included various electronic databases such as PubMed, WOS, Scopus, Embase, Science Direct, and Google Scholar. The search criteria encompassed articles published in English up until January 1, 2024.
Results: In the initial search of the relevant databases, 3288 articles were identified and transferred to the information management software (EndNote). A thorough analysis was conducted on a total of 39 studies with varying sample sizes. Among these studies, hypothyroidism was found to be the most common thyroid disorder following radiation therapy for breast cancer, accounting for 40% of the cases. The findings indicate that radiation doses ranging from 20 to 40 Gray- particularly those exceeding 36 Gray-can contribute to the development of hypothyroidism.
Conclusion: The research lightened the significant effect of radiation therapy on the thyroid gland. It is recommended to adopt improved techniques and protective measures to protect the thyroid during radiation treatment. Additionally, regular monitoring of breast cancer patients after radiation therapy is essential to better assess any potential dysfunction of the thyroid gland. |
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| کلیدواژه‌های انگلیسی مقاله |
Thyroid gland,Breast cancer,Radiation therapy,Radiation-induced damage,Dose |
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| نویسندگان مقاله |
Maliheh Dayani |
Department of Radiation Oncology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Kazhal Veisi |
Preclinical Lab, Core Facility, Kermanshah University of Medical Sciences, Kermanshah, Iran
Tinoosh Almasi |
Department of Medical Physics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Nima Rostampour |
Department of Medical Physics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
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| نشانی اینترنتی |
http://irjnm.tums.ac.ir/article_40441_4cce985fcffd44afd9ca9a9680bb69b4.pdf |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
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