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Middle East Journal of Cancer، جلد ۸، شماره ۲، صفحات ۷۷-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of a Number of Blood Biochemical Markers after Radioiodine Therapy in Papillary Thyroid Cancer Patients |
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| چکیده انگلیسی مقاله |
Background: This study aimed to assess several biochemical and oxidative stress parameters before and after radioiodine therapy in patients with well-differentiated thyroid cancer who consumed a low iodine diet and withdrawal of levothyroxine after total thyroidectomy. Methods: We enrolled 40 candidates for radioiodine therapy. Blood sampling was performed prior to as well as 72 h after consumption of 125-200 mCi of 131I. Total protein, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and creatinine were measured. Oxidative stress parameters that included malondialdehyde and protein carbonyl levels were also assessed. Results: There were significantly decreased total protein, creatinine, aspartate aminotransferase, and alanine aminotransferase levels ( P < 0.001) after treatment. However, malondialdehyde levels increased significantly ( P < 0.05) over the studied time. Conclusion: We found that radioactive iodine absorption in peripheral tissues due to a low-iodine diet and levothyroxine withdrawal could relieve iodine deficiency in the liver and kidneys which resulted in reduced total protein, aspartate aminotransferase, alanine aminotransferase, and creatinine levels. However, it induced oxidative stress by increasing malondialdehyde levels in the blood. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
mehrossadat علوی | mehrossadat alavi
medical imaging research center, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
فاطمه زال | fatemeh zal
biochemistry department, medical school, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
فهیمه زمانی | fahimeh zamani
biochemistry department, medical school, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
مهدی کاظمی | mehdi kazemi
nuclear medicine department, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
مژگان راستی | mozhgan rasti
biochemistry department, medical school, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
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| نشانی اینترنتی |
http://mejc.sums.ac.ir/index.php/mejc/article/view/458 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/181/article-181-351043.pdf |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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