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مجله تغذیه و امنیت غذایی، جلد ۱۰، شماره ۲، صفحات ۱۹۴-۲۰۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of Zinc Gluconate Supplementation on C-Reactive Protein and Malondialdehyde in Patients with Behcet's Disease: A Double-Blind Randomized Controlled Clinical Trial
چکیده انگلیسی مقاله
Background:  Behçet's disease (BD) with autoimmune and auto-inflammatory nature is more prevalent in Silk Road countries. The current study aimed to investigate the effect of zinc gluconate supplementation on C-reactive protein (CRP) and malondialdehyde (MDA) levels in BD patients. Methods: This randomized controlled clinical trial was conducted on 50 Iranian BD patients. Participants were randomly assigned into either placebo or zinc gluconate (30 mg/day) groups for 12 weeks. Before and after the intervention, serum MDA and CRP levels were measured. Results: Zinc supplementation led to a significant increase in serum zinc levels compared to the placebo group (P<0.05). There was no significant difference in MDA serum levels between the groups after adjusting for the baseline values and confounding factors (P>0.05). Zinc supplementation led to a significant improvement in CRP serum levels compared to the placebo group following adjustment for the effect of baseline values and confounding factors (P=0.012 and 0.04, respectively). Conclusion: Zinc supplementation in an elemental dose of 30 mg per day has an anti-inflammatory effect in BD patients by reducing CRP levels. The beneficial effect of zinc on lipid peroxidation in BD patients was not shown in the study.
 
کلیدواژه‌های انگلیسی مقاله Malondialdehyde, Zinc, CRP, Behcet disease.
نویسندگان مقاله | Amir Hossein Faghfouri
Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran


| Seyyed Morteza Seyyed Shoura
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran


| Ghazaleh shahhosseini
Department of Dentistry, Islamic Azad university, Tehran, Iran


| Amir Arshia Khodabandehloo
4Department of Converging Sciences and Technologies, Islamic Azad University Science and Research Branch ,Tehran, Iran


| Pourya Fathollahia
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran


| Alireza Khabbazi
Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


| Vali Musazadeh
Student research committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran


| Beitullah Alipour
Department of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
نشانی اینترنتی http://jnfs.ssu.ac.ir/browse.php?a_code=A-10-257-2&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده public specific
نوع مقاله منتشر شده orginal article
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