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Journal of Medical Bacteriology، جلد ۱۳، شماره ۲، صفحات ۸۵-۱۰۷
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عنوان انگلیسی Vaccination against Pathogenic Bacteria: An Insight into Polysaccharide and Conjugate Vaccines
چکیده انگلیسی مقاله Background:   The cellular glycocalyx, a dense and complex coating of glycans, surrounds the surface of cells and serves as a critical interface between the cell and its external environment. Within this glycocalyx, the intricate glycans play essential roles in a variety of biological processes, including mediating cell-cell interactions, facilitating bacterial pathogenicity, and providing protection against environmental stressors such as desiccation, immune responses, and antimicrobial agents. The polysaccharides found on the outer surface of bacterial cells are particularly noteworthy due to their high degree of conservation across species and their easy accessibility. These characteristics make them excellent targets for immunological purposes, as they can be readily recognized by the immune system. As a result, bacterial polysaccharides and their repetitive units have been extensively studied and utilized as antigens in the development of vaccines with antibacterial properties. These vaccines leverage the unique structural features of polysaccharides to elicit robust and specific immune responses, offering a promising strategy for combating bacterial infections and enhancing public health. Conclusion:   In conclusion, it is important to emphasize that the topic explored in this article is vast, and the research field has experienced rapid growth in recent decades with ongoing advancements. Given the breadth of this field, it is challenging to cover the entire spectrum of polysaccharide-based bacterial vaccines targeting all bacterial pathogens. Additionally, due to inherent limitations, it was not feasible to include all research on polysaccharide and glycoconjugate vaccine development for a comprehensive set of bacterial pathogens. Therefore, only a subset of common bacteria and related vaccine development efforts have been evaluated in this discussion. Despite these limitations, the progress made in this area underscores the potential of polysaccharide-based vaccines as a powerful tool in the fight against bacterial infections.
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نویسندگان مقاله | Mina Shirmohammadpour
Department of Microbiology and Virology, Zanjan University of Medical Sciences, Zanjan, Iran


| Bahman Mirzaei
Department of Microbiology and Virology, Zanjan University of Medical Sciences, Zanjan, Iran
نشانی اینترنتی https://jmb.tums.ac.ir/index.php/jmb/article/view/554
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