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Journal of Medical Bacteriology، جلد ۱۳، شماره ۲، صفحات ۵۴-۶۲
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عنوان انگلیسی Ventilator-Associated Pneumonia in COVID-19 Patients: Prevalence and Associated Factors
چکیده انگلیسی مقاله Background:   COVID 19 pandemic has resulted in increased ICU admission, with many patients requiring mechanical ventilation resulting in more incidences of ventilator associated pneumonia (VAP). Despite vast research on COVID 19 complications, very few studies have looked at the risk factors of VAP in this population. The purpose of this study is to bridge this gap by identifying clinical and laboratory predictors of VAP in critically ill COVID-19 patients. Methods:   Shahid Beheshti Hospital, Kashan was the site of a retrospective analysis of 235 COVID 19 ICU patients requiring mechanical ventilation. Therapeutic interventions were assessed and clinical symptoms, laboratory markers were assessed. Results:   Fever and chills were also found to be associated with nearly a threefold increase in risk (p < 0.05) as was abnormal heart rate, which increased the risk fourfold (p < 0.001), and WBC and ESR significantly correlated with VAP occurrence. In addition, patients not treated with tocilizumab had a sixfold increase in risk of VAP (p < 0.001). Early identification and targeted interventions to mitigate the risk of VAP in COVID-19 patients being mechanically ventilated is a focus of this study. Conclusion:   Results indicate immunomodulatory therapy may provide a protective role, and underscore the importance of strict infection control. Future research should model causal mechanisms and develop best treatment strategies to reduce the incidence of VAP.
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نویسندگان مقاله | Mahdi Bozorgi
Department of Infectious Diseases, Assistant Professor of Infectious Diseases, Kashan School of Medicine, Kashan University of Medical Sciences Kashan Iran


| Mohammad Javad Azadchehr
Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran


| Saina Najafi
Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Najmeh Sedighimehr
Department of Physiotherapy, School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Javad Fathi
Department of Bacteriology and Virology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Hamed Pahlevani
Department of Anesthesiology, Kashan School of Medicine Kashan University of Medical Sciences Kashan Iran.


| Maedeh Najafizadeh
Department of Infectious Diseases, Assistant Professor of Infectious Diseases, Kashan School of Medicine, Kashan University of Medical Sciences Kashan Iran
نشانی اینترنتی https://jmb.tums.ac.ir/index.php/jmb/article/view/561
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